吡唑酮化合物在催化不对称反应中的应用  

Application of Pyrazolone Compounds in Catalytic Asymmetric Reactions

作　　者：李路瑶[1] 徐鑫尧 朱博 常俊标 Luyao Li;Xinyao Xu;Bo Zhu;Junbiao Chang(School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang 453007,China)

机构地区：[1]河南师范大学化学化工学院,新乡453007

出　　处：《化学进展》2020年第11期1710-1728,共19页Progress in Chemistry

基　　金：国家自然科学基金项目(No.81903465,U1804283)资助。

摘　　要：吡唑-5-酮类化合物在具有生物活性化合物中占有重要地位,该类化合物得到化学家们的广泛关注。吡唑-5-酮及其常见衍生物具有多个反应位点,可参与多种类型的不对称反应(如不对称加成反应、不对称环化反应和其他不对称反应类型)。本文主要从吡唑-5-酮类化合物参与的不对称催化反应类型进行分类,阐述了各类底物参与的反应类型及其主要反应位点,对近年来吡唑酮及其常见衍生物参与的不对称反应研究进展进行总结,并对其未来发展方向进行展望。Pyrazolin-5-one compounds play an important role in bioactive compounds and have attracted extensive attention.Pyrazolin-5-one and its common derivatives have many reaction sites and can participate in a variety of asymmetric reactions,such as asymmetric addition reactions,asymmetric annulation reactions and other asymmetric reactions.In this context,we summarize the recent progress in asymmetric reactions of pyrazolin-5-one and its common derivatives.The main reaction types involving the pyrazolin-5-one compounds are classified,and their main reaction sites are expounded.Finally,the challenges and development of pyrazolone derivatives are summarized,and the future development direction is prospected.

关 键 词：吡唑酮化合物 不对称催化 加成反应 环化反应 

分 类 号：O621.34[理学—有机化学] O626.21[理学—化学]