益气清热散结法治疗气阴两虚型良性甲状腺结节临床疗效观察  

Clinical Observation of Applying Replenishing Qi,Clearing Away Heat and Resolving Hard Masses Method in the Treatment of Qi-Yin Deficiency Type Benign Thyroid Nodules

作　　者：丛亿蕾 杨昕宇 吴腾飞[1] 乔齐 冯圣钰 唐红[1] 杨华[1] CONG Yilei;YANG Xinyu;WU Tengfei(Endocrinology Department,Longhua Hospital Attached to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属龙华医院内分泌科,上海200032

出　　处：《四川中医》2020年第11期151-154,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:观察益气清热散结法对气阴两虚型良性甲状腺结节大小及中医症候改善情况。方法:本课题通过随机、平行、对照的临床试验研究方法,将符合纳入标准的62例气阴两虚型良性甲状腺结节患者分为治疗组(益气清热散结组)及空白对照组,观察时间12周。治疗组予益气清热散结方颗粒剂口服,每天两次,每次100ml,对照组不服用任何甲状腺相关药物。治疗前后观察两组患者彩超下甲状腺结节最大结节长短径、甲状腺功能及自身抗体、中医证候积分和安全性指标(血常规、肝肾功能)等项目,对改善甲状腺结节大小、临床症状进行评价。结果:甲状腺最大结节长短径比较:治疗组和对照组最大结节长径、短径比较有明显差异(P均<0.001)。甲状腺功能、甲状腺自身抗体比较:治疗组和对照组甲状腺功能、甲状腺自身抗体没有明显差异(P均>0.05)。中医证候积分比较:治疗组和对照组主症积分、次症积分和总积分比较有明显差异(P均<0.001)。治疗组临床疗效:治疗组临床痊愈1例、显效6例、有效15例、无效8例,总有效率为73.33%。结论:益气清热散结法治疗气阴两虚型良性甲状腺结节可有效缩小甲状腺结节大小,有效改善患者临床症状,并且不会引起患者甲状腺功能及自身抗体明显波动,可安全应用于临床治疗甲状腺结节的治疗。Objective:To observe the efficacy of applying replenishing Qi,clearing away heat and resolving hard masses method in the treatment of Qi-Yin deficiency type benign thyroid nodules.Methods:The subject adopted the clinical research method of randomized,parallel and control study.62 patients of benign thyroid nodules with syndrome of Qi-Yin deficiency who were in accordance with the inclusive criteria were randomized into treatment group and blank controlled group.The treatment lasted 12 weeks.The treatment group was given granule based on TCM method of replenishing Qi,clearing away heat and resolving hard masses orally(2 doses a day,100 ml per dose).The blank controlled group was asked not to take any thyroid-related medicines.Observing items include the biggest nodule’s size,thyriod function,thyroid auto-antibodies and traditional Chinese medicine syndrome score.To complete the evaluation of clinical efficacy about TCM method of replenishing Qi,clearing away heat and resolving hard masses treating benign thyroid nodules with syndrome of Qi-Yin deficiency.Results:The contrast of long and short diameters of the biggest nodule after the observation of 12 weeks,the long and short diameters of the biggest nodule in the treatment groups had significantly differences(P<0.001).The contrast of thyroid function and thyroid auto-antibodies after the observation of 12 weeks,there were no significantdifferences in thyroid function and thyroid auto-antibodies in both groups(P>0.05).The contrast of traditional Chinese medicine syndrome score after the observation of 12 weeks,the two groups had significant differences in the syndrome scores(P<0.001).The clinical curative effect after 12-week treatment,1 case cured,6 cases markedly effective,15 cases effective,8 cases ineffective,the total effective rate was 73.33%.Conclusion:On the treatment of benign thyroid nodules with syndrome of Qi-Yin deficiency,TCM method of replenishing Qi,clearing away heat and resolving hard masses can effectively reduce the size of benign thyroid nod

关 键 词：良性甲状腺结节 气阴两虚 益气清热散结法 

分 类 号：R581.3[医药卫生—内分泌]