桂枝附子汤治疗寒湿痹阻型骨性关节炎临床研究  

Clinical Study on Guizhi Fuzi Decoction in the Treatment of Cold-dampness Blockade Osteoarthritis

作　　者：江共涛[1] 程毅[1] 胡和军[1] 魏星星[1] 徐南云[1] JIANG Gongtao;CHENG Yi;HU Hejun;WEI Xingxing;XU Nanyun(Department of Trauma and Orthopaedics,Hongdu Hospital of Traditional Chinese Medicine,Jiangxi Province,Nanchang 330008,China)

机构地区：[1]江西省南昌市洪都中医院创伤骨科,江西南昌330008

出　　处：《中国中医药现代远程教育》2020年第22期76-78,共3页Chinese Medicine Modern Distance Education of China

基　　金：江西省卫生计生委中医药科研课题项目【No.2018A157】。

摘　　要：目的观察桂枝附子汤治疗寒湿痹阻型骨性关节炎的疗效以及安全性。方法选取2017年4月—2019年4月收治的80例寒湿痹阻证型骨性关节炎患者,将其按照随机数字表法均分为试验组和对照组。对照组40例采取单纯西药(塞来昔布胶囊)进行治疗,试验组在对照组的基础上采取中药桂枝附子汤进行治疗。比较2组治疗前后患者的关节肿胀、畏寒以及麻木等临床症状。观察和比较2组治疗前后IL-1、IL-7以及TNF-α的含量变化,评价2组患者的临床疗效,并且观察2组的不良反应发生情况。结果经过治疗,试验组总的有效率为92.50%,明显高于对照组72.50%,差异均具有统计学意义(P<0.05)。2组均能改善关节肿胀、畏寒以及麻木等临床症状,并且有效降低关节液炎性因子TNF-α、IL-1以及IL-7的分泌水平,其中试验组较对照组效果更佳,其与治疗前比较具有显著性差异(P<0.05)。结论桂枝附子汤具有良好的祛风除湿、温经散寒的功效,对于寒湿痹阻型骨性关节炎,可明显改善患者的临床症状,降低患者关节液中的炎症因子的表达,且临床疗效良好,值得广泛推广应用。Objective To observe the efficacy and safety of Guizhi Fuzi decoction in the treatment of cold-dampness blockade osteoarthritis.Methods Eighty patients with cold-dampness blockade osteoarthritis admitted to our hospital from April 2017 to April 2019 were enrolled.The patients were divided into the experimental group and the control group according to the random number expression method.In the control group,40 patients were treated with western medicine(celecoxib capsule).The experimental group was treated with Chinese medicine Guizhi Fuzi decoction on the basis of the control group.Clinical symptoms such as joint swelling,chills and numbness were compared between the two groups before and after treatment.The changes of IL-1,IL-7 and TNF-αlevels before and after treatment were observed and compared.The clinical efficacy of the two groups was evaluated and the adverse reactions of the two groups were observed.Results After treatment,the total effective rate of the experimental group was 92.50%,which was significantly higher than that of the control group(72.50%).The difference was statistically significant(P<0.05).Both groups can improve the clinical symptoms such as joint swelling,chills and numbness,and effectively reduce the secretion levels of inflammatory factors such as TNF-α,IL-1 and IL-7.The experimental group was better than the control group.There was significant difference(P<0.05)Compared with before treatment.Conclusion Guizhi Fuzi decoction has good effects of hurricane dehumidification,warming and dispelling cold.It can significantly improve the clinical symptoms and reduce the inflammatory factors in the joint fluid of patients with dysentery and cold dampness and obstructive osteoarthritis.The expression,and clinical efficacy is good,and it is worthy of widespread application.

关 键 词：桂枝附子汤 寒湿痹阻 骨性关节炎 中医药疗法 痹证 

分 类 号：R274.9[医药卫生—中西医结合]