间充质干细胞治疗椎间盘退行性疾病:基于Web of Science数据库的文献计量及可视化分析  

Mesenchymal stem cells for treatment of intervertebral disc degeneration:a bibliometric and visualization analysis based on Web of Science database

作　　者：张凯 张晓勃 施锦涛 王克平 周海宇[1,2,3] Zhang Kai;Zhang Xiaobo;Shi Jintao;Wang Keping;Zhou Haiyu(Department of Orthopedics,Lanzhou University Second Hospital,Lanzhou 730030,Gansu Province,China;Key Laboratory of Bone and Joint Disease Research of Gansu Province,Lanzhou 730030,Gansu Province,China;Department of Orthopedics,Xigu Hospital of Lanzhou University Second Hospital,Lanzhou 730060,Gansu Province,China)

机构地区：[1]兰州大学第二医院骨科,甘肃省兰州市730030 [2]甘肃省骨与关节疾病研究重点实验室,甘肃省兰州市730030 [3]兰州市西固区人民医院骨科,甘肃省兰州市730060

出　　处：《中国组织工程研究》2021年第19期3031-3038,共8页Chinese Journal of Tissue Engineering Research

基　　金：兰州市和西固区科技支撑计划项目(2018-3-79),项目负责人:周海宇。

摘　　要：背景:间充质干细胞具有自我更新和多向分化的特性,在治疗椎间盘疾病中具有巨大的潜力和应用前景。目的:针对间充质干细胞治疗椎间盘退行性疾病相关文献进行文献计量学分析,了解该领域的研究热点、发展趋势,为其后续发展提供依据和建议。方法:以间充质干细胞治疗椎间盘退行性疾病为主题,检索2000至2019年Web of Science核心合集收录的相关文献,统计文献的年发文量、科研基金资助情况,并采用Citespace 5.5.R2软件分析作者、国家和机构的合作关系、期刊或文献的共被引情况,最后对关键词进行聚类分析、突现分析及时区图分析,并绘制出可视化的知识图谱。结果与结论:①共纳入648篇文献,文献类型以期刊论文为主要形式;②科研基金以中国和美国资助项目最多(占基金总数的50%以上);③共纳入作者206位,发文量≥3篇的有70位,主要研究者有Daisuke Sakai(日本)关注间充质干细胞移植治疗椎间盘退变、Judith A Hoyland(英国)关注间充质干细胞对髓核细胞表型的调节、Makarand V Risbud(美国)关注诱导间充质干细胞向髓核细胞分化;④共纳入国家和机构125个,主要国家为中国和美国;⑤共纳入期刊154个,《SPINE》杂志是收录文章最多的期刊;⑥关键词分析显示,该领域研究可分为3个阶段:第1阶段为2005至2012年,主要研究基因表达差异、间充质干细胞软骨分化、椎间盘细胞外基质改变;第2阶段为2012至2017年,主要研究间充质干细胞注射治疗及椎间盘微环境变化;第3阶段为2017至2019年,主要研究细胞疗法及间充质干细胞促进椎间盘再生;⑥结合热点关键词变化,文章预测未来的研究方向为提取培养间充质干细胞并诱导向髓核细胞分化、间充质干细胞旁分泌对椎间盘细胞作用及间充质干细胞结合组织工程技术促进椎间盘再生。BACKGROUND: Mesenchymal stem cells have the characteristics of self-renewal and multi-directional differentiation, and have great potential and applicationprospects in the treatment of intervertebral disc diseases.OBJECTIVE: To analyze the literature of mesenchymal stem cells in the treatment of intervertebral disc degenerative diseases using bibliometric analysis, and tounderstand the research trends and hotspots in this field, and to provide basis and suggestions for its follow-up development.METHODS: With the theme of mesenchymal stem cell therapy for intervertebral disc degeneration, we searched the relevant literature included in the Webof Science database from 2000 to 2019, analyzed the annual number of paper published, and scientific research funding. Citespace5.5.R2 software was usedto analyze the cooperation relationship of authors, countries and research institutions, the co-citation of journals or literatures. Finally, cluster analysis, burstanalysis and time zone graph analysis were performed on keywords.RESULTS AND CONCLUSION: (1) A total of 648 papers were included, with journal articles as the main type of literature. (2) Most of the funding weresponsored by China and USA (more than 50%). (3) A total of 206 authors were included, out of whom 70 authors published more than 3 papers, and theprincipal researchers were Daisuke Sakai (Japan) focusing on mesenchymal stem cells transplantation for intervertebral disc degeneration, Judith A Hoyland(Great Britain) focusing on regulation of myeloid cell phenotype by mesenchymal stem cells, and Makarand V Risbud (US) focusing on induction of mesenchymalstem cell differentiation. (4) 125 countries and institutions were included: China and USA were the two main countries. (5) 154 journals were included, as SPINEwas the journal with the most published articles. (6) The keyword analysis showed that the research in this field can be divided into three phases: phase 1 from2005 to 2012, mainly investigating gene expression differences, chondrogenic differentiation o

关 键 词：干细胞 间充质干细胞 椎间盘 椎间盘退行性疾病 髓核细胞 Citespace 文献计量学 可视化分析 

分 类 号：R459.9[医药卫生—治疗学] R363[医药卫生—临床医学]