创伤性脑外伤促进骨折愈合中的干细胞、细胞因子、激素、神经肽及基因  

Stem cells,cytokines,hormones,neuropeptides and genes in traumatic brain trauma to promote fracture healing

作　　者：李祥泽 卜宪敏[2] 李冬梅[3] 池玉磊 苏强 靳欣桐 赵键 张高天 吴彬[3] 孟纯阳[3] Li Xiangze;Bu Xianmin;Li Dongmei;Chi Yulei;Su Qiang;Jin Xintong;Zhao Jian;Zhang Gaotian;Wu Bin;Meng Chunyang(Clinical Institute,Jining Medical University,Jining 272000,Shandong Province,China;Jining No.1 People’s Hospital,Jining 272000,Shandong Province,China;Department of Orthopedics,Affiliated Hospital of Jining Medical University,Jining 272000,Shandong Province,China)

机构地区：[1]济宁医学院临床医学院,山东省济宁市272000 [2]济宁市第一人民医院,山东省济宁市272000 [3]济宁医学院附属医院骨科,山东省济宁市272000

出　　处：《中国组织工程研究》2021年第19期3057-3063,共7页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(81572205),项目负责人:孟纯阳;山东省自然科学基金(ZR2014CQ042),项目负责人:吴彬;济宁医学院教师扶持基金(JYFC2018FKJ048),项目负责人:吴彬;济宁医学院贺林院士基金(JYHL2018FMS13),项目负责人:吴彬。

摘　　要：背景:骨折延迟愈合和不愈合是临床常见的并发症,脑外伤促进骨折愈合的机制是目前研究的热点。目的:总结创伤性脑外伤促进骨折愈合机制的最新研究进展,为临床应用提供理论依据。方法:文章第一作者通过检索中国知网、万方、维普、PubMed、Embase和Web of Science数据库2009年1月至2020年3月相关文献,检索词为“创伤性脑外伤,骨折愈合,骨髓间充质干细胞,脂肪干细胞,细胞因子,激素,神经肽,基因”“traumatic brain injury,fracture healing,bone marrow mesenchymal stem cells,fat stem cells,cytokines,hormones,neuropeptides,genes”。最终选取符合纳入标准的文献共计63篇。结果与结论:骨折愈合是一个复杂而有序的病理过程,涉及多种病理生理机制,且众多因素影响骨再生。大量的临床研究表明创伤性脑外伤可以促进骨折愈合,但其修复骨折的具体机制尚没有一个系统的定论,目前相关的研究均是针对一种或几种因素单独作用的检测,对所有有关因素系统研究、动态检测存在空缺,因此在今后的临床研究中应整体观察脑外伤后骨再生过程中相关因素在不同时间点的表达情况,并进一步探究其相互间的作用机制,从而为临床上骨折不愈合、延迟骨折愈合、异位骨化提供充分的理论依据并指导临床治疗。BACKGROUND:Delayed fracture healing and nonunion are common complications in clinic.The mechanism of brain injury promoting fracture healing is the focus of current research.OBJECTIVE:To summarize the latest research progress on the mechanism of promoting fracture healing by traumatic brain injury,and provide theoretical basis for clinical application.METHODS:The first author searched CNKI,Wanfang,VIP,PubMed,Embase and Web of Science databases from January 2009 to March 2020.Search terms were“traumatic brain injury,fracture healing,bone marrow mesenchymal stem cells,fat stem cells,cytokines,hormones,neuropeptides,genes”in Chinese and English.Totally,63 articles that met the inclusion criteria were selected.RESULTS AND CONCLUSION:Fracture healing is a complex and orderly pathological process,involving a variety of pathophysiological mechanisms and many factors affect bone regeneration.Large numbers of clinical studies have shown that traumatic brain injury can promote healing of fracture,but there is no systematic conclusion on the specific mechanism of fracture repair.Moreover,the current research is aimed at detection of the role of one or several factors alone.There are gaps in systematic research and dynamic detection of all relevant factors.Therefore,in the future clinical research,we should observe the expression of related factors at different time points during post-traumatic bone regeneration,and further explore the action mechanism of their interaction,so as to provide sufficient theoretical basis for clinical fracture nonunion,delayed fracture healing,heterotopic ossification and guide clinical treatment.

关 键 词：脑外伤 骨折 骨髓间充质干细胞 脂肪干细胞 细胞因子 激素 神经肽 基因 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学]