间充质干细胞外泌体应用于生殖系统疾病治疗的作用与机制  

Role and mechanism of exosomes derived from mesenchymal stem cells in reproductive system diseases

作　　者：赵双丹 郑嘉华[1] 亓文博 黄向华[1] Zhao Shuangdan;Zheng Jiahua;Qi Wenbo;Huang Xianghua(Department of Obstetrics and Gynecology,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,Hebei Province,China)

机构地区：[1]河北医科大学第二医院妇产科,河北省石家庄市050000

出　　处：《中国组织工程研究》2021年第19期3097-3102,共6页Chinese Journal of Tissue Engineering Research

摘　　要：背景:间充质干细胞是再生医学领域最常用的细胞类型之一。近年来研究发现,间充质干细胞来源外泌体在某些生殖系统疾病中发挥重要作用,并且逐渐成为生殖领域研究的热点。目的:综述间充质干细胞来源外泌体在卵巢早衰、多囊卵巢综合征、宫腔粘连和常见生殖系统肿瘤等疾病中的研究进展,并对间充质干细胞来源外泌体在未来的应用与研究进行了探讨。方法:在PubMed和CNKI数据库中进行相关文献检索,关键词为“mesenchymal stem cells,exosome,premature ovarian insufficiency,premature ovarian failure,polycystic ovary syndrome,intrauterine adhesions,endometrium,Asherman’s syndrome,ovarian cancer,cervical cancer,endometrial carcinoma,embryo”及“间充质干细胞,外泌体,原发性卵巢功能不全,卵巢早衰,多囊卵巢综合征,宫腔粘连,卵巢癌,宫颈癌,子宫内膜癌,胚胎”,纳入56篇文献进行综述。结果与结论:间充质干细胞来源外泌体不仅可以作为某些生殖系统疾病的治疗载体,更有可能成为研究疾病发生机制的重要靶点。间充质干细胞来源外泌体有望成为一种新兴的“无细胞”疗法用于生殖系统疾病的治疗。BACKGROUND:Mesenchymal stem cells are one of the most commonly used cell types in regenerative medicine.In recent years,exosomes derived from mesenchymal stem cells play an important role in some reproductive diseases and have become a new hot spot of research in the field of reproductive medicine.OBJECTIVE:To review the research progress of exosomes derived from mesenchymal stem cells in premature ovarian failure,polycystic ovary syndrome,intrauterine adhesions and common reproductive system tumors,and discuss the application and research of exosomes derived from mesenchymal stem cells in the future.METHODS:The literature search was performed in PubMed and CNKI databases,and the key words were“mesenchymal stem cells,exosome,premature ovarian insufficiency,premature ovarian failure,polycystic ovary syndrome,intrauterine adhesions,endometrium,Asherman’s syndrome,ovarian cancer,cervical cancer,endometrial carcinoma,embryo”in English and Chinese,respectively.Fifty-six articles were finally reviewed.RESULTS AND CONCLUSION:Exosomes derived from mesenchymal stem cells can not only be used as a therapeutic carrier for some reproductive diseases,but also become an important target for studying the pathogenesis of diseases.Exosome derived from mesenchymal stem cells is expected to become a new“cellfree”therapy for reproductive system diseases.

关 键 词：干细胞 间充质干细胞 外泌体 卵巢早衰 多囊卵巢综合征 宫腔粘连 卵巢癌 宫颈癌 子宫内膜癌 生殖系统 综述 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学]