益气活血化瘀方对冠心病老年患者PCI术后冠状动脉血流的影响  

Effect of Yiqi Huoxue Huayu Formula on Coronary Blood Flow in Elderly Patients with CHD after PCI

作　　者：吴炜 樊丹 朱玉婕[1] 陈永刚[1] WU Wei;FAN Dan;ZHU Yujie;CHEN Yonggang(Xuzhou Central Hospital,Xuzhou 221000,China)

机构地区：[1]徐州市中心医院,江苏徐州221000

出　　处：《中医药学报》2020年第12期50-53,共4页Acta Chinese Medicine and Pharmacology

摘　　要：目的:研究益气活血化瘀方对冠心病(CHD)老年患者经皮冠状动脉介入治疗(PCI)后冠状动脉血流的影响。方法:选取2018年2月—2019年5月于我院接受治疗的CHD老年患者106例,采用随机数字表法分为观察组和对照组各53例,对照组患者PCI术后接受抗凝血、降血脂及血压等常规西药治疗,观察组患者在对照组基础上采用益气活血化瘀方治疗,治疗结束后观察比较两组临床疗效、中医证候积分、冠脉血流参数[舒张期峰流(DPV)、收缩期峰流速(SPV)、冠状动脉血流储备(CFVR)、舒张期时间速度积分(CTVI)]和血清一氧化氮(NO)、内皮素-1(ET-1)、血液流变学指标[高切黏度、低切黏度、红细胞压积、纤维蛋白原]水平。结果:观察组总有效率(88.68%、47/53)明显高于对照组(71.70%、38/53)(P<0.05);治疗前,两组中医证候积分、DPV、SPV、CFVR、CTVI、血液流变学指标水平及血清组NO、ET-1水平比较差异无统计学意义(P>0.05);治疗后,两组中医证候积分和血清ET-1、血液流变学指标水平与治疗前比较显著下降(P<0.05),DPV、SPV、CFVR、CTVI水平和血清NO水平较本组治疗前明显升高(P<0.05),对照组中医证候积分和血清ET-1、血液流变学指标水平明显高于观察组,DPV、SPV、CFVR、CTVI水平和血清NO水平明显低于观察组(P<0.05)。结论:益气活血化瘀方治疗PCI术后CHD老年患者,能有效改善患者冠状动脉血流,促进临床症状消失,进而提高临床疗效。Objective:To investigate the effect of Yiqi Huoxue Huayu Formula on coronary blood flow in elderly patients with coronary heart disease(CHD)after percutaneous coronary intervention(PCI).Methods:106 CHD patients underwent PCI were randomly divided into the control group and the observation group,with 53 cases in each group.The control group was given the routine treatment including the treatment of anti-coagulation and lipid-lowering and blood pressure control;on which basis,the observation group was also treated with Yiqi Huoxue Huayu Formula.Clinical efficacy,TCM syndrome scores,coronary blood flow parameters,such as diastolic peak velocity(DPV),systolic peak velocity(SPV),coronary flow velocity reserve(CFVR)and diastolic time velocity integral(CTVI),as well as serum levels of nitric oxide(NO)and endothelin-1(ET-1)and the levels of hemorheology indexes(high shear viscosity,low shear viscosity,hematocrit and fibrinogen)were compared between the two groups after the treatment.Results:The total effective rate was 88.68%(47/53)in the observation group,which was significantly higher than 71.70%(38/53)in the control group(P<0.05).There were no statistical differences in TCM syndrome scores,DPV,SPV,CFVR,CTVI,hemorheology indexes,and the levels of NO and ET-1 between the two groups before the treatment(P>0.05).The TCM syndrome scores,hemorheology indexes and serum level of ET-1 were significantly decreased,and the levels of DPV,SPV,CFVR,CTVI and serum NO were significantly increased after the treatment than those before the treatment in the two groups(P<0.05),of which the improvements in the observation group were more significant(P<0.05).Conclusion:Yiqi Huoxue Huayu Formula can effectively improve the coronary blood flow,relieve clinical symptoms and improve the clinical efficacy in the elderly patients with CHD after PCI.

关 键 词：冠心病 PCI术 益气活血化瘀 冠状动脉血流 

分 类 号：R256.22[医药卫生—中医内科学]