HIP-55介导胞内信号转导的分子机制研究  

Molecular mechanisms of HIP-55 signal transduction pathways

作　　者：陈星卉 韩峰 卢应梅 CHEN Xing-hui;HAN Feng;LU Ying-mei(Key Lab of Cardiovascular & Cerebrovascular Medicine,School of Pharmacy,Nanjing Medical University,Nanjing 211166,China;School of Medicine, Zhejiang University City College, Hangzhou 310015, China;Dept of Physiology, Nanjing Medical University, Nanjing 211166, China)

机构地区：[1]南京医科大学药学院,心脑血管病重点实验室,江苏南京211166 [2]浙江大学城市学院,医学院,浙江杭州310015 [3]南京医科大学基础医学院,生理系,江苏南京211166

出　　处：《中国药理学通报》2020年第12期1655-1659,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金面上项目(No 81673415)。

摘　　要：HIP-55(HPK1-interacting protein of 55 ku,又名DBNL,SH3P7,mAbp1)是一种与HPK-1相结合分子量为55 ku,由多个具有蛋白相互作用结构域构成的接头蛋白。其N端含有肌动蛋白结合结构域C端具有SH3结构域。HIP-55能够通过细胞内信号转导调控细胞内吞、迁移、骨架重排等生物功能并且在多种疾病病理生理过程中发挥重要作用。该文将对HIP-55蛋白生物学功能及其胞内信号转导通路参与疾病病理过程分子机制进行综述。HIP-55(HPK1-interacting protein of 55 ku,also named DBNL,SH3P7,mAbp1)identified a HPK1-interacting protein of 55 ku,composed of protein interaction structure domain adapter protein.The N-terminal contains the actin binding domain and the C-terminal has the SH3 domain.Hip-55 regulates cell endocytosis,migration,skeletal rearrangement and plays an important role in the pathophysiological process of various diseases.Here,we review the biological function and intracellular signaling pathway of Hip-55 protein and focus on its intracellular signaling transduction pathway involved in the pathological process of disease.

关 键 词：HIP-55 接头蛋白 肌动蛋白 SH3结构域 胞内信号转导 分子机制 

分 类 号：R329.24[医药卫生—人体解剖和组织胚胎学] R329.25[医药卫生—基础医学]