BL19U2:Small-angle X-ray scattering beamline for biological macromolecules in solution at SSRF  

作　　者：Yi-Wen Li Guang-Feng Liu Hong-Jin Wu Ping Zhou Chun-Xia Hong Na Li Feng-Gang Bian 

机构地区：[1]Shanghai Advanced Research Institute(Zhangjiang Laboratory),Chinese Academy of Sciences,Shanghai 201204,China [2]CAS Key Laboratory of Molecular Virology and Immunology,Institute Pasteur of Shanghai,Chinese Academy of Sciences,Shanghai 200031,China [3]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Nuclear Science and Techniques》2020年第12期32-40,共9页核技术（英文）

基　　金：the National Natural Science Foundation of China(Nos.U1832215 and U1832144);the Youth Innovation Promotion Association of Chinese Academy Science(No.2017319).

摘　　要：The BL19U2 at the Shanghai Synchrotron Radiation Facility is a small-angle X-ray scattering beamline dedicated to structural studies pertaining to biological macromolecules in solution.The beamline has been officially opened to users in March 2015,and since then,a series of technological innovations has been developed to optimize beamline performance,thereby significantly improving the data collection efficiency and broadening the application scope of biological small-angle X-ray scattering.BL19U2 is ideal for the high-throughput screening of weakly scattered proteins,protein assemblies,nucleic acids,inorganic nanomaterials,and organic drug molecules.This paper describes the design and overview of the BL19U2 beamline.Versatile sample environments at the experimental station and some recent scientific highlights are presented.

关 键 词：Shanghai synchrotron radiation facility Biological small-angle X-ray scattering High-throughput screening Biological macromolecules 

分 类 号：Q503[生物学—生物化学]