苦楝茎叶化学成分研究  

Chemical Constituents from the Stems and Leaves of Melia azedarach L.

作　　者：刘全裕 冯珊[1] 杨宏芳[1] LIU Quan-yu;FENG Shan;YANG Hong-fang(Pharmacy Department of Fujian Health College,Fuzhou 350101,China)

机构地区：[1]福建卫生职业技术学院药学系,福建福州350101

出　　处：《海峡药学》2020年第11期44-46,共3页Strait Pharmaceutical Journal

基　　金：福建省教育厅中青年教师教育科研项目(No.JZ180549),福建省卫生计生青年科研项目(No.2016-2-38)。

摘　　要：目的研究苦楝(Melia azedarach L.)茎叶的化学成分。方法通过硅胶柱层析(CC)、Sephadex LH-20柱层析、微孔树脂柱层析(MCI)等实验手段对苦楝茎叶石油醚萃取层化学成分进行分离纯化。利用其理化性质以及IR、EI-MS、1H-NMR、13 C-NMR等波谱技术鉴定化合物结构。结果从苦楝茎叶中分离得到10个化合物(1~10),分别鉴定为β-谷甾醇(1),β-胡萝卜苷(2),三十烷酸(3),二十八烷醇(4),羽扇豆醇(5),β-香树脂醇(6),α-香树脂醇(7),乙酰香树脂醇(8),2β,3β-二羟基香树脂醇(9),3,7-O-二甲基槲皮素(10)。结论化合物5~10均首次从该植物的茎叶中分离得到。OBJECTIVE To study the chemical constituents of the stems and leaves of Melia azedarach L.METHODS The chemical constituents were isolated and purified by means of various chromatographic techniques such as silica gel,Sephadex LH-20,MCI,and their structures were identified on the basis of physicochemical properties and spectroscopic data analysis such as IR,EI-MS,1H-NMR,13 C-NMR.RESULTS Ten compounds were isolated and identified asβ-sitosterol(1),β-sitosterol glucoside(2),triacontanic acid(3),octadecanol(4),lupeol(5),β-amyrin(6),α-amyrin(7),amyrin acetate(8),2β,3β-dihydroxy amyrin(9),3,7-O-dimethyl quercetin(10).CONCLUSION Compounds 5-10 were isolated from the stems and leaves of Melia azedarach L.for the first time.

关 键 词：苦楝 化学成分 甾醇 黄酮 

分 类 号：R284[医药卫生—中药学]