Clinical Evaluation on Xiyanping Injection in the Treatment of Bronchopneumonia in Children Based on Meta-Analysis  

作　　者：Cheng Zhang Jian Lyu Yan-Ming Xie Meng-Hua Sun 

机构地区：[1]Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China

出　　处：《World Journal of Traditional Chinese Medicine》2020年第3期307-323,共17页世界中医药杂志（英文）

基　　金：National Key R&D Program of China(2018YFC1707400);Funding for Basic Scientific Research Business Expenses of Central-Level Non-Profit Research Institutes(Z0597)。

摘　　要：Objective:The aim of this study is to evaluate the effectiveness and safety of xiyanping injection(XYPI)in the treatment of children with bronchopneumonia.Methods:Asystematic and comprehensive search was conducted in the domestic and foreign electronic databases CNKI,SinoMed,VIP,WanFang DATA,PubMed,The Cochrane Library,Embase,Web of Science,Clinical‑Trials.gov,and the search date ended on May 30,2019.Inclusion criteria:(1)the types of studies included were randomized controlled trials;(2)the study participants were infants and children with a clear diagnosis of bronchopneumonia,without gender and ethnic restrictions;(3)the intervention test group was XYPI or the control group plus XYPI.The control group was routine treatment(RT)(basic treatment such as fever,cough and asthma,oxygen inhalation,anti‑infection,maintaining water,electrolyte balance,etc.)or other Western medicine or RT+other Western medicine treatment.Except for XYPI,the two groups were consistent in intervention measures.According to the Cochrane Handbook,5.1 evaluation standard and a meta‑analysis of the final included studies was performed using RevMan 5.3 software.Results:Atotal of 57 studies were included,with a total sample size of 8454 cases,of which 4255 were in the experimental group and 4199 were in the control group.Meta‑analysis results showed that(1)Total effective rate:XYPI group was better than the control group(relative risk[RRRT]=1.25,95%confidence interval[CI][1.15,1.36],P<0.00001;RRRT+RBVI=1.18,95%CI[1.09,1.29],P<0.0001;RR antibiotic=1.16,95%CI[1.09,1.24],P<0.00001,RRRT+antibiotic=1.22,95%CI[1.16,1.27],P<0.00001);antipyretic time:XYPI group was better than the control group(mean difference[MDRT]=−0.97,95%CI[−1.17,−0.76],P<0.00001;MDRT+antibiotic=−2.28,95%CI[−2.88,−1.67],P<0.00001;MDRT+RBVI=−1.51,95%CI[−1.81,−1.21],P<0.00001;cough disappearing time:XYPI group was better than the control group(MDRT=−1.37,95%CI[−1.74,−1.00],P<0.00001;MDRT+antibiotic=−1.71,95%CI[−2.04,−1.37],P<0.00001;MDRT+RBVI=−1

关 键 词：META-ANALYSIS pediatric bronchopneumonia systematic review xiyanping injection 

分 类 号：R272[医药卫生—中医儿科学]