福建省2018年0-61岁社区人群白喉抗体水平调查  

Diphtheria antibody levels among a community-dwelling population aged 0-61 years in Fujian province,2018

作　　者：陈致飞 张海荣 王琴 张苏晗 李东 杨秀惠 周勇[1,2] 郑奎城 Chen Zhifei;Zhang Hairong;Wang Qin;Zhang Suhan;Li Dong;Yang Xiuhui;Zhou Yong;Zheng Kuicheng(Fujian Provincial Key Laboratory of Zoonosis Research/Fujian Provincial Center for Disease Control and Prevention,Fuzhou 350001,Fujian,China;Teaching Base of Public Health School of Fujian Medical University,Fuzhou 350001,Fujian,China)

机构地区：[1]福建省人兽共患病研究重点实验室/福建省疾病防控制中心,福建福州350001 [2]福建医科大学公共卫生学院教学基地,福建福州350001

出　　处：《中国疫苗和免疫》2020年第5期521-524,共4页Chinese Journal of Vaccines and Immunization

基　　金：福建省科技创新平台建设项目(2019Y2001)。

摘　　要：目的了解福建省2018年社区人群白喉抗体水平。方法采用分层随机抽样方法在福建省18个县区选择0-61岁(15个年龄组)社区人群开展调查和采集血清标本,应用酶联免疫吸附试验检测白喉抗毒素IgG抗体,分析抗体阳性率和几何平均浓度(GMC)。结果共纳入4925名调查对象,白喉抗毒素IgG抗体总阳性率为56.16%(标化率:33.26%),GMC(95%CI)为0.15(0.14-0.16)IU/mL。0-14、15-61岁人群白喉IgG抗体阳性率分别为77.89%、28.60%(x2=1197.59,P=0.00),GMC分别为0.30、0.06IU/mL(t=45.07,P=0.00);各年龄组抗体阳性率在14.91%(30-39岁)-91.30%(2岁)之间(趋势x2=1109.08,P=0.00)。0、1-3、≥4剂次白喉免疫史人群抗体阳性率分别为24.28%、74.77%、76.56%(x2=1277.05,P=0.00),GMC分别为0.06、0.25、0.29IU/mL(F=1065.80,P=0.00)。结论福建省≥15岁社区人群白喉抗体水平显著低于<15岁儿童。建议制定成人白喉免疫策略以降低成人白喉发病风险。Objective To determine diphtheria antibody levels among a community-dwelling population in Fujian province in 2018.Methods We used stratified random sampling method to select a 0-61-year-old community-dwelling population(15 age groups)from 18 counties of Fujian for survey and serum sample collection.We tested for IgG antibodies against diphtheria antitoxin using enzyme-linked immunosorbent assay and analyzed positivity rates and geometric mean concentrations(GMC)of antibody.Results A total of 4925 subjects were included.The overall positivity rate of IgG antibody against diphtheria antitoxin was 56.16%(adjusted:33.26%),with a GMC(95%CI)of 0.15(0.14-0.16)IU/mL.Positivity rates for 0-14-and 15-61-year-olds were 77.89%and 28.60%(x2=1197.59,P=0.00),with GMCs of 0.30 and 0.06 IU/mL(t=45.07,P=0.00),respectively.Positivity rates by age group ranged from 14.91%(30-39 years old)to 91.30%(2 years old)(trend x2=1109.08,P=0.00).Positivity rates for people who had received 0,1-3,and≥4 doses of diphtheria vaccine were 24.28%,74.77%,and 76.56%(x2=1277.05,P=0.00),with GMCs of 0.06,0.25,and 0.29 IU/mL(F=1065.80,P=0.00).Conclusions Diphtheria antibody levels were significantly lower among≥15-year-old community dwellers than among<15-year-old children in Fujian.We suggest developing adult diphtheria immunization strategies to reduce risk of adult diphtheria.

关 键 词：白喉 抗体水平 社区人群 

分 类 号：R186[医药卫生—流行病学]