低温刺激影响气道黏蛋白分泌与AECOPD  

Low temperature affects airway mucin secretion and promotes acute exacerbation of chronic obstructive pulmonary disease

作　　者：张丽娜[1] 吴铁军[1] 张喜红[1] Zhang Lina;Wu Tiejun;Zhang Xihong(Department of Intensive Care Uint,Liaocheng People's Hospital,Liaocheng 252000,Shandong,China)

机构地区：[1]聊城市人民医院重症医学科,山东聊城252000

出　　处：《中华危重病急救医学》2020年第10期1273-1276,共4页Chinese Critical Care Medicine

基　　金：山东省自然科学基金(ZR2015HQ023);山东省医药卫生科技发展计划项目(2014WS0047)。

摘　　要：慢性阻塞性肺疾病(COPD)发病率较高,可导致不可逆性肺功能障碍。防止COPD急性加重(AECOPD)、延缓病情进展为其治疗的重点,但目前尚缺乏确切有效的预防措施。AECOPD一个显著的特点是冬季高发,传统观念认为冬季冷空气可伴有病毒复制增加、环境污染、空气湿度降低等,各种混杂因素交织促进AECOPD的发生,而对于低温本身所造成的影响,一直被忽视。近年来,随着分子生物学的发展,越来越多的研究表明,气道黏蛋白分泌异常可导致气道黏液清除障碍,增加感染率,参与COPD的发生发展,而低温可通过多种机制影响黏蛋白分泌。本文对COPD气道温度的特殊性以及低温导致黏蛋白变化的相关途径进行总结,以期引起人们对低温的重视,并为预测及预防AECOPD发生提供新的干预途径的思想与方法。Chronic obstructive pulmonary disease(COPD)has a high incidence,and leads to irreversible lung dysfunction.Preventing COPD acute exacerbation(AECOPD)and delaying the progression of the disease are the focus of treatment.However,there is still a lack of precise and effective preventive measures.A significant feature of AECOPD is the high incidence in winter.The traditional concept is that cold air in winter can be accompanied by increased virus replication,environmental pollution,and reduced air humidity.Various confounding factors intertwine to promote the occurrence of AECOPD,and the impact of low temperature itself has been neglected.In recent years,with the development of molecular biology,more and more studies have found that abnormal secretion of airway mucin can lead to obstruction of mucus clearance,increase the chance of infection,and participate in the development of COPD.Low temperature can affect mucin secretion through various mechanisms.This article summarizes the particularity of COPD airway temperature and the related ways of low temperature leading to mucin changes.It draws people's attention to low temperature in order to carry out basic research and provide new intervention methods for predicting and preventing the occurrence of AECOPD.

关 键 词：慢性阻塞性肺疾病 急性加重 低温 黏蛋白 

分 类 号：R563.9[医药卫生—呼吸系统]