缺血性心肌病连续应用左西孟旦对心功能的影响  

The Effect of Levosimendan on Patients with Ischemic Cardiomyopathy

作　　者：任岩春[1] 赵永峰[1] 张晓蕾[1] 王硕 董静杰 杨艳[1] REN Yanchun;ZHAO Yongfeng;ZHANG Xiaolei;WANG Shuo;DONG Jingjie;YANG Yan(Department of Cardiology,First Hospital of Shijiazhuang,Shijiazhuang 050011, China)

机构地区：[1]石家庄市第一医院心内科,河北石家庄050011

出　　处：《标记免疫分析与临床》2020年第11期1904-1906,1924,共4页Labeled Immunoassays and Clinical Medicine

基　　金：石家庄市科学技术研究与发展指导计划项目(编号:161462603)。

摘　　要：目的探讨缺血性心肌病间隔一周两次应用左西孟旦对心功能的影响。方法入选我院2016年12月至2017年12月收治的缺血性心肌病患者32例,随机分为左西孟旦组16例和对照组16例,两组患者均给予缺血性心肌病的常规治疗,其中左西孟旦组间隔1周予以静脉泵入左西孟旦2次,分别于入院时及入院后1周时泵入左西孟旦,后观察血浆NT-proBNP及左室射血分数等。结果与对照组相比,左西孟旦组患者的NT-proBNP水平及左室射血分数均有明显的改善,左西孟旦组NT-proBNP在治疗过程中逐渐下降但第二次泵入左西孟旦后射血分数未再进一步提高。结论左西孟旦可使缺血性心肌病患者心功能有所改善,但多次反复应用可能仅保持心功能水平,而无进一步提高。Objective To investigate the effect of levosimendan on patients with ischemic cardiomyopathy.Methods 32 patients admitted in our hospital from December,2016 to December,2017 with ischemic cardiopathy were randomly divided into two groups:levosimendan group(n=16)and control group(n=16).The levosimendan group was administered with levosimendan at admission and a week after admission.NT-ProBNP and LVEF were treated at admission,a week and 2 weeks after admission in all patients.Results The levels of NT-ProBNP and LVEF were significantly improved compared with the control group(P<0.01).NT-proBNP level in patients with levosimendan declined in a continuous manner,but after the second injection,it failed to improved further.Conclusion Levosimendan on patients with ischemic cardiomyopathy can improve cardiac function,but reuse cannot further improve the heart function.

关 键 词：左西孟旦 缺血性心肌病 NT-PROBNP 左室射血分数 

分 类 号：R542.2[医药卫生—心血管疾病]