原发性肾小球肾炎患者uPAR、NAG及TNFR1的表达及其与患者肾功能相关性的研究  

The Expressions and Clinical Significances of uPAR,NAG and TNFR1 in Patients with Primary Glomerulonephritis

作　　者：曾莉[1] 何敬东[1] 卿山林 田中[1] 骆强 ZENG Li;HE Jingdong;QING Shanlin;TIAN Zhong;LUO Qiang(Department of Nephrology,Second Affiliated Hospital of Chengdu Medical College(NineteenSixteen Hospital of Nuclear Industry),Chengdu 610051,China)

机构地区：[1]成都医学院附属第二医院(核工业四一六医院)肾内科,四川成都610051

出　　处：《标记免疫分析与临床》2020年第11期1920-1924,共5页Labeled Immunoassays and Clinical Medicine

摘　　要：目的探讨原发性肾小球肾炎(primary glomerulonephritis,PGN)患者尿激酶型纤溶酶原激活剂受体(urokinase type plasminogen activator receptor,uPAR)、尿N-乙酰-B-D氨基葡萄糖苷酶(urine N-acetyl-B-D glucosaminidase,NAG)及肿瘤坏死因子α特异性的膜受体1(tumor necrosis factor receptor 1,TNFR1)的表达及其与患者肾功能的相关性。方法选取2018年1月至2019年12月本院收治的60例PGN患者为PGN组,另选取来自本院体检的同期年龄相仿的60例健康人员作为对照组。收集所有研究对象的临床资料,对比对照组人员体检当日和PGN组患者治疗前血清肌酐(serum creatinine,Scr)、血尿酸(urine acid,UA)、血尿素氮(blood urea nitrogen,BUN)、uPAR、NAG及TNFR1水平,采用Pearson相关性分析uPAR、NAG及TNFR1与各肾功能指标之间的相关性。结果PGN组患者的Scr、UA及BUN各肾功能指标水平均明显高于对照组,差异有统计学意义(P<0.05)。PGN组患者的uPAR、NAG及TNFR1水平均明显高于对照组,差异有统计学意义(P<0.05)。uPAR、NAG及TNFR1与Scr、UA及BUN各肾功能指标均呈存在正相关关系(P<0.05)。受试者工作特征曲线(receiver operating characteristic curve,ROC)显示,uPAR、NAG及TNFR1预测PGN发生的AUC值分别为0.795、0.834、0.886,三者联合检测的AUC值为0.951,明显高于各单一指标(P<0.05)。结论PGN患者的uPAR、NAG及TNFR1水平较健康人明显上升,且与患者肾功能密切相关,对临床疾病判定和病情监测有积极意义。Objective To explore the expressions and clinical significances of urokinase-type plasminogen activator receptor(uPAR),urine N-acetyl-BD glucosaminidase(NAG)and tumor necrosis factor receptor 1(TNFR1)in patients with primary glomerulonephritis(PGN)Methods Sixty PGN patients who were admitted to the hospital from January,2018 to December,2019 were enrolled as the PGN group,while 60 healthy people with a similar age range who underwent physical examination in the hospital during the same period were enrolled as the control group.Their clinical data were collected for the analysis.The levels of serum creatinine(Scr),blood uric acid(UA),blood urea nitrogen(BUN),uPAR,NAG and TNFR1 were compared between the control group on the day of physical examination and the PGN group before treatment.The correlation between uPAR,NAG,TNFR1 and renal function indexes was analyzed by Pearson correlation analysis.Results The levels of Scr,UA and BUN in the PGN group were significantly higher than those in the control group(P<0.05).The levels of uPAR,NAG and TNFR1 in the PGN group were significantly higher than those in the control group(P<0.05).uPAR,NAG and TNFR1 levels were positively correlated with Scr,UA and BUN levels(P<0.05).The receiver operating characteristic(ROC)curves showed that AUC values of uPAR,NAG and TNFR1 for predicting PGN were 0.795,0.834 and 0.886,respectively.AUC of the three-marker combination was 0.951,which was significantly higher than that of single index(P<0.05).Conclusion The levels of uPAR,NAG and TNFR1 in PGN patients are significantly higher than those in healthy people,which are closely related to their renal function,and are of positive significance for clinical diseases determining and conditions monitoring.

关 键 词：原发性肾小球肾炎 尿激酶型纤溶酶原激活剂受体 尿N-乙酰-B-D氨基葡萄糖苷酶 肿瘤坏死因子α特异性的膜受体1 

分 类 号：R692.6[医药卫生—泌尿科学]