腰大池引流联合鞘内注射庆大霉素治疗颅脑术后颅内感染的临床研究  

Lumbar Cistern Drainage Combined with Intrathecal Injection of Gentamicin in the Treatment of Intracranial Infection after Craniocerebral Surgery

作　　者：王文光[1] 汪超[1] 朱凤娥[1] WANG Wenguang;WANG Chao;ZHU Feng’e(Hebei Province Zhuozhou City Hospital,Zhuozhou 072750,China)

机构地区：[1]河北省涿州市医院,河北涿州072750

出　　处：《中国医学创新》2020年第31期14-17,共4页Medical Innovation of China

基　　金：河北省科学计划与发展指导计划项目(17ZF092)。

摘　　要：目的:探讨腰大池引流联合鞘内注射庆大霉素治疗颅脑术后颅内感染的效果及安全性。方法:选取2017年1月-2018年12月本院收治的颅脑术后颅内感染患者108例,按随机数字表法将其分为观察组(n=54)和对照组(n=54)。对照组进行鞘内注射庆大霉素治疗,观察组进行腰大池引流联合鞘内注射庆大霉素治疗。比较两组治疗前与治疗7 d后体温、颅内压及脑脊液相关指标、治疗第7天的临床疗效及不良反应发生情况。结果:观察组治疗7 d后颅内压、蛋白定量和白细胞均低于对照组,而葡萄糖含量明显高于对照组(P<0.05)。观察组治疗总有效率为92.6%高于对照组的77.8%(P<0.05)。观察组不良反应发生率为27.8%低于对照组的66.7%(P<0.05)。结论:腰大池引流联合鞘内注射庆大霉素治疗颅脑术后颅内感染的效果较好,安全性较高,值得临床推广应用。Objective:To investigation the efficacy and safety of lumbar cistern drainage combined with intrathecal injection of Gentamicin in the treatment of intracranial infection after craniocerebral surgery.Method:A total of 108 patients with intracranial infection after craniocerebral surgery admitted to our hospital from January 2017 to December 2018 were selected.They were divided into observation group (n=54) and control group (n=54) according to the random number table method.The control group was treated with intrathecal injection of Gentamicin,and the observation group was treated with lumbar cistern drainage combined with intrathecal injection of Gentamicin.Temperature,intracranial pressure and cerebrospinal fluid related indicators before and after 7 d of treatment,clinical efficacy on the 7th day of treatment and adverse reactions were compared between the two groups.Result:After 7 d of treatment,intracranial pressure,protein quantification and white blood cells in the observation group were lower than those in the control group,while glucose content was significantly higher than that in the control group (P<0.05).The total effective rate in the observation group was 92.6% higher than 77.8% in the control group (P<0.05).The incidence of adverse reactions in the observation group was 27.8% lower than 66.7% in the control group (P<0.05).Conclusion:Lumbar cistern drainage combined with intrathecal injection of Gentamicin is effective and safe in the treatment of intracranial infection after craniocerebral surgery,which is worthy of clinical application.

关 键 词：颅脑术后 颅内感染 腰大池引流 鞘内注射 庆大霉素 

分 类 号：R651.1[医药卫生—外科学]