脉冲震荡和常规肺功能检查在儿童哮喘中的相关性研究  

Correlation between impulse oscillometry and routine pulmonary function tests in asthma in children

作　　者：黄丽珍 郝创利[1] 蒋吴君[1,2] 张金红 林颖 沈美菊 HUANG Lizhen;HAO Chuangli;JIANG Wujun;ZHANG Jinhong;LIN Ying;SHEN Meiju(Pneumology Department,Children's Hospital of Soochow University,Suzhou 215008,Jiangsu,China;Children's Hospital of Wujiang District,Suzhou 215200,Jiangsu,China)

机构地区：[1]苏州大学附属儿童医院呼吸科,江苏苏州215008 [2]苏州市吴江区儿童医院,江苏苏州215200

出　　处：《临床儿科杂志》2020年第12期896-899,共4页Journal of Clinical Pediatrics

摘　　要：目的探讨哮喘儿童脉冲震荡(IOS)和常规肺功能检查(PFT)各参数的相关性。方法以2019年5月至12月就诊的哮喘儿童作为研究对象,患儿就诊当天先行IOS后行PFT检测,分析两种不同肺功能检查方法之间的相关性。结果共纳入患儿180例,男109例、女71例,中位年龄8岁。急性发作期5Hz时呼吸道黏性阻力R5、R5-R20(20Hz时呼吸道黏性阻力)、5Hz时电抗的绝对值(|X5|)及响应频率(Fres)显著高于慢性持续期和临床缓解期,差异有统计学意义(P<0.01)。在3~6岁年龄段,一秒用力呼气容积(FEV1)与R5、R5-R20、|X5|呈强相关;一秒率(FEV1/FVC)与R5、R5-R20呈强相关。在7~15岁,FEV1与R5呈中等程度相关;FEV1/FVC与R5、R20呈中等程度相关。结论IOS与PFT在哮喘儿童中存在良好的相关性,在3~6岁年龄段相关性更强。IOS能较好地反映周边小气道功能,比PFT更加敏感。Objective To explore the correlation between impulse oscillometry(IOS)and routine pulmonary function tests(PFT)in asthmatic children.Methods The children with asthma visited from May to December 2019 were included as the research objects.On the same day of visiting,IOS and subsequent PFT test were performed to analyze the correlation between the two different lung function test methods.Results A total of 180 children(109 boys and 71 girls)were included and a median age was 8 years.During the acute stage,the airway resistance at 5 Hz(R5),resistance at 5 Hz minus resistance at 20 Hz(R5-R20),the absolute value of reactance at 5 Hz(|X5|)and the resonant frequency(Fres)were significantly higher than those in the chronic stage and clinical remission stage,and the differences were statistically significant(P<0.01).In the group of 3-6 year age,the forced expiratory volume in 1 second(FEV1)is strongly correlated with R5,R5-R20 and|X 5|.Furthermore,the one-second rate(FEV1/FVC)is strongly correlated with R 5 and R 5-R20.At the group of 7-15 year age,FEV 1 and R 5 were moderately correlated,and FEV1/FVC was moderately correlated with R 5 and R 20.Conclusions There was a good correlation between IOS and PFT in asthmatic children,especially in the group of 3-6 year age.IOS is better reflect peripheral small airway function and is more sensitive than PFT.

关 键 词：脉冲震荡肺功能 常规肺功能 支气管哮喘 儿童 

分 类 号：R725.6[医药卫生—儿科]