Heiner综合征2例报告并文献复习  

Heiner syndrome:a report of 2 cases and literature review

作　　者：郦琳琳[1] 王全[1] 赵德育[1] 刘峰[1] 黄霞[1] LI Linlin;WANG Quan;ZHAO Deyu;LIU Feng;HUANG Xia(Department of Respiratory,Children’s Hospital Affiliated to Nanjing Medical University,Nanjing 210008,Jiangsu,China)

机构地区：[1]南京医科大学附属儿童医院呼吸科,江苏南京210008

出　　处：《临床儿科杂志》2020年第12期940-944,共5页Journal of Clinical Pediatrics

摘　　要：目的探讨Heiner综合征的临床特征。方法回顾分析2例Heiner综合征患儿的临床资料。以“Heiner syndrome”及“Heiner综合征”为关键词,检索PubMed和万方数据知识服务平台于2020年2月前收录的论文,并进行分析。结果2例男孩年龄分别为1个月8天和4个月14天,出生后均以配方奶喂养,反复出现呼吸道感染、肺部弥漫性病变、贫血,肺泡灌洗液含铁血黄素细胞阳性。检索到国外病例25例,国内病例2例,联合本组2例患儿,生后均以配方奶喂养,以反复咳嗽喘息、发热、贫血及生长发育迟缓为主要表现,肺部影像学表现为斑片样浸润影;回避牛奶饮食后呼吸道及全身症状缓解。结论Heiner综合征罕见,临床诊断困难。Objective To explore the clinical features of Heiner syndrome.Methods The clinical data of Heiner syndrome in 2 children were retrospectively analyzed.The literatures before February 2020 were collected by the search in PubMed and Wanfang database using keywords“Heiner syndrome”and“Heiner syndrome”and analyzed.Results There were two boys aged 1 month 8 days and 4 months 14 days respectively and they were fed with formula milk after birth.They had recurrent respiratory infections,diffuse lung lesions and anemia.The alveolar lavage fluid was found to be positive for hemosiderin cells.Twenty-five foreign cases and two domestic cases in literatures plus two children in this study were all fed with formula milk after birth.They were characterized by recurrent coughing,wheezing,fever,anemia and growth retardation,and the imaging findings of the lungs showed patchy infiltration.Respiratory and systemic symptoms were relieved after avoidance of cow’s milk diet.Conclusion Heiner syndrome is rare and clinical diagnosis is difficult.

关 键 词：Heiner综合征 牛奶蛋白过敏 肺部弥漫性病变 

分 类 号：R725.6[医药卫生—儿科]