氯霉素泼尼松搽剂抗炎、抗过敏和止痒作用动物实验研究  

Experimental Study on Anti-Inflammatory,Anti-Allergic and Anti-Pruritic Effects of Chloramphenicol Prednisone Liniment in Animals

作　　者：陈少秀 杜晓 景海霞 张霞 常明泉 Chen Shaoxiu;Du Xiao;Jing Haixia;Zhang Xia;Chang Mingquan(Shiyan Taihe Hospital,Affiliated Hospital of Hubei University of Medicine,Hubei Shiyan 442000,China)

机构地区：[1]十堰市太和医院,湖北医药学院附属医院,湖北十堰442000

出　　处：《儿科药学杂志》2020年第12期1-3,共3页Journal of Pediatric Pharmacy

基　　金：十堰市太和医院院级基金项目,编号2017JJXM056。

摘　　要：目的:研究氯霉素泼尼松搽剂的抗炎、抗过敏和止痒作用,为临床应用提供参考。方法:利用二甲苯诱导小鼠耳朵肿胀观察氯霉素泼尼松搽剂的抗炎作用;利用2,4-二硝基氯苯(DNCB)诱导小鼠迟发性过敏反应观察氯霉素泼尼松搽剂的抗过敏作用;利用4-氨基吡啶(4-AP)诱导小鼠皮肤过敏性瘙痒观察氯霉素泼尼松搽剂的止痒作用。结果:与模型对照组比较,氯霉素泼尼松搽剂能显著减轻二甲苯所致小鼠耳朵肿胀程度,同时降低DNCB诱导的小鼠过敏反应,并能明显减少4-AP诱导小鼠瘙痒的舔体次数、延长瘙痒潜伏期、缩短瘙痒持续时间。结论:氯霉素泼尼松搽剂具有明显的抗炎、抗过敏和止痒作用。Objective:To study the anti-inflammatory,anti-allergic and anti-pruritic effects of chloramphenicol prednisone liniment in animals,so as to provide reference for clinical application.Methods:Anti-inflammatory effects of chloramphenicol prednisone liniment were observed in mice with xylene-induced ear swelling.Anti-allergic effects of chloramphenicol prednisone liniment were observed in mice with delayed-type hypersensitivity induced by 2,4-dinitrochlorobenzene(DNCB).Anti-pruritus effects of chloramphenicol prednisone liniment were observed in mice with skin allergic itching induced by 4-aminopyridine(4-AP).Results:Compared with the model control group,chloramphenicol prednisone liniment could significantly alleviate xylene-induced ear swelling in mice and reduce DNCB-induced allergic reaction in mice.Chloramphenicol prednisone liniment could reduce the number of carcasses induced by 4-AP in mice,prolong pruritus latency and shorten the duration of pruritus.Conclusion:Chloramphenicol prednisone liniment has significant anti-inflammatory,anti-allergic and anti-pruritus effects.

关 键 词：氯霉素泼尼松搽剂 抗炎 抗过敏 止痒 

分 类 号：R927.2[医药卫生—药学]