基于大环化合物的刺激响应组装体的研究进展  

Progress in Stimuli-Responsive Assemblies Based on Macrocyclic Compounds

作　　者：何祖政 谢冰倩 刘慧[1] HE Zuzheng;XIE Bingqian;LIU Hui(School of Chemical Engineering and Pharmacy,Wuhan Institute of Technology,Wuhan 430205,China)

机构地区：[1]武汉工程大学化工与制药学院,湖北武汉430205

出　　处：《武汉工程大学学报》2020年第6期597-603,共7页Journal of Wuhan Institute of Technology

基　　金：武汉工程大学研究生教育创新基金(CX2019015)。

摘　　要：由可逆的非共价相互作用形成的超分子组装体引起了极大的关注。大环主体因其独特的主客体性质是构建超分子组装体的主要部分。大环化合物的多样性导致形成了极好的亲和性和选择性的超分子组装体,这些超分子组装体可以通过改变主体的空腔来调节。通过外部刺激,例如光、pH、氧化还原反应来控制组装体。通过利用主客体之间的可逆性,已经成功地制备了具有刺激响应功能的材料和传感器。冠醚的结构简单且易于官能化,环糊精和葫芦脲在水介质中显示出更高的溶解度,而柱芳烃的刚性结构则易于形成有机体。因此,有望将这些动态组装体应用于纳米技术、药物递送等领域。亚纳米级和微米级超分子组装体如胶体和囊泡将成为未来智能设备的发展趋势。Supramolecular assemblies formed by reversible noncovalent interactions have attracted tremendous attentions.Macrocyclic hosts are a useful building block to construct the assembly architectures with their unique host-guest properties.A varieties of supramolecular assemblies with fascinating affinities and selectivities are formed based on the diversities of macrocyclic compounds.And these assemblies could be tuned by changing the cavity of the host.External stimuli such as photo,pH value,redox,were used for controlling these assemblies.By taking advantage of the reversibility between the host and the guest,materials and sensors have been successfully prepared with stimuli-responsive functions.The structures of crown ethers are simple and readily functionalizable.Cyclodextrins and cucurbit[n]urils exhibit higher solubility in aqueous media,and the rigid conformations of pillar[n]arenes make them easily preorganize.Therefore it is promising to apply these dynamic assemblies into the field of nanotechnology,drug delivery and so on.The subnanometer-and micrometer-scale supramolecular assemblies like colloids and vesicles would be the future trend for smart devices.

关 键 词：大环化合物 刺激响应 超分子组装体 

分 类 号：O641.3[理学—物理化学]