渗透树脂联合生物活性玻璃修复脱矿牙釉质的效果及稳定性  

Restoration effect and stability of resin infiltration combined with bioactive glass on demineralized tooth enamel

作　　者：程亚楠[1] 吴毓聪 毛秋华[1] 陈灵[1] 陆丽英[1] 徐普[1] Cheng Yanan;Wu Yucong;Mao Qiuhua;Chen Ling;Lu Liying;Xu Pu(Affiliated Haikou Hospital,Xiangya Medical School,Central South University,Hainan Provincial Stomatology Center,Haikou 570208,Hainan Province,China)

机构地区：[1]中南大学湘雅医学院附属海口医院·海南省口腔医学中心,海南省海口市570208

出　　处：《中国组织工程研究》2021年第22期3522-3526,共5页Chinese Journal of Tissue Engineering Research

基　　金：海南省重点研发项目(ZDYF2016018),项目负责人:徐普。

摘　　要：背景:渗透树脂是一种修复釉质初期龋的有效方式,但近期研究发现其存在抗脱矿能力不足、聚集收缩、易老化、颜色稳定性较差等缺陷。目的:观察渗透树脂联合生物活性玻璃修复脱矿牙釉质的效果及稳定性。方法:收集临床因正畸治疗拔除的磨牙100颗,建立人工牙釉质脱矿模型后随机分4组进行再矿化处理:A组浸于人工唾液中;B组进行渗透树脂处理后浸于人工唾液中;C组进行渗透树脂处理后以氟化钠(2次/d)处理,最后浸于人工唾液中;D组进行渗透树脂处理后以生物活性玻璃(2次/d)处理,最后浸于人工唾液中,4组再矿化处理时间为4周。再矿化处理后,将4组进行再脱矿处理,72 h后取出。于处理前、脱矿后、再矿化处理后及再脱矿处理后分别进行光学相干断层成像扫描、牙釉质表面粗糙度及牙釉质显微硬度检测。结果与结论:①光学相干断层成像扫描显示,处理前,各组牙釉质表面平滑,信号最强,组间无差异;初次脱矿后,各组牙釉质表面略不平,信号增强区域向表面以下延伸,且组间无差异;再矿化后和再脱矿处理后,信号增强区域向表面以下延伸更加明显,且D组牙釉质表面信号增强区域减弱较其他各组更显著;②处理前与初次脱矿处理后,4组间牙釉质表面粗糙度比较差异无显著性意义(P﹥0.05);再矿化处理后,粗糙度值大小为:A组>B组>C组>D组,组间比较差异均有显著性意义(P<0.01);再脱矿处理后,A组粗糙度值高于初次脱矿后(P<0.01),B、C、D组低于初次脱矿后(P<0.01);③处理前与初次脱矿处理后,4组间牙釉质显微硬度比较差异无显著性意义(P﹥0.05);再矿化处理后,显微硬度值大小为:A组<B组<C组<D组,组间比较差异均有显著性意义(P<0.01);再脱矿处理后,A组显微硬度值低于初次脱矿后(P<0.01),B、C、D组高于初次脱矿后(P<0.01);④结果表明,渗透树脂联合生物活性玻璃修复牙釉质脱矿的效果BACKGROUND:Resin infiltration is an effective way to repair the initial caries of enamel,but recent studies have found that it has defects such as insufficient anti-mineralization ability,aggregation shrinkage,easy aging and poor color stability.OBJECTIVE:To observe the restoration effect and stability of resin infiltration combined with bioactive glass on demineralized tooth enamel.METHODS:100 isolated human tooth specimens were selected to establish an artificial enamel demineralization model,which were randomly divided into four groups and received remineralization treatment.In the group A,models were immersed in artificial saliva.In the group B,the models were immersed in artificial saliva after resin infiltration treatment.In the group C,the models were treated with resin infiltration and then treated with sodium fluoride(twice a day),and finally immersed in artificial saliva.In the group D,the models were treated with resin infiltration and treated with bioactive glass(twice a day),and finally immersed in artificial saliva.The remineralization time of the four groups was 4 weeks.After remineralization,the four groups were re-demineralized and removed after 72 hours.Optical coherence tomography,enamel surface roughness and enamel microhardness were measured before treatment,after demineralization,after remineralization and after re-demineralization.RESULTS AND CONCLUSION:(1)Optical coherence tomography scan showed that the enamel surface of each group was smooth before treatment;the signal was strongest;and there was no difference between the groups.After the initial demineralization,the surface of each group was slightly uneven;the signal enhancement region extended below the surface;and there was no difference between the groups.After remineralization and re-demineralization,the signal enhancement region extended more obviously below the surface,and the signal enhancement region of group D enamel surface was weakened more significantly than other groups.(2)Before treatment and after initial demineralizatio

关 键 词：材料 渗透树脂 生物活性玻璃 再矿化 再脱矿 表面粗糙度 显微硬度 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学]