组织工程用水凝胶研发现状和发展趋势:基于专利信息的分析  

Research and development status and development trend of hydrogel in tissue engineering based on patent information

作　　者：刘利永[1,2] 周雷 Liu Liyong;Zhou Lei(Beijing Institute of Science and Technology Information,Beijing 100044,China;Beijing Science and Technology Strategic Decision Consulting Center,Beijing 100044,China)

机构地区：[1]北京市科学技术情报研究所,北京市100044 [2]北京科技战略决策咨询中心,北京市100044

出　　处：《中国组织工程研究》2021年第22期3527-3533,共7页Chinese Journal of Tissue Engineering Research

摘　　要：背景:水凝胶由于其独特的柔韧性和生物相容性,而使得其在组织工程中发挥重要作用。而专利是最为重要的技术信息载体,因此,利用专利信息计量学对其中所含的信息进行统计、萃取和比较,对于研究具有重要参考价值。目的:利用专利信息识别和发现水凝胶在组织工程中的技术分布、研发重点、发展趋势,以及国别竞争态势。方法:利用德温特专利数据库为数据源,检索近30年相关领域所有专利申请,并使用统计分析、社区聚类分析以及发展路径分析,对领域内主要技术分布、国别优势、保护范围、技术路径、核心专利和主要专利权人进行研究分析。结果与结论:文章通过对组织工程中水凝胶领域的专利分析,客观反映了水凝胶在组织工程中专利技术的规模、布局和趋势:①在专利技术分布上,水凝胶在组织工程中的主要研发领域可分为填充剂、释控载体、生物高分子水凝胶和制备技术等4个部分,其中生物高分子水凝胶技术是研发的主体;②在专利研发重点上,良好的生物相容性和可降解性是设计的主要目标,并且在技术上,以蛋白质/多肽及植物多糖等为主要材料、金属配位键交联和辐射法为主要合成工艺;③在专利发展趋势上,干细胞和纳米技术深度介入,纳米纤维素和多潜能干细胞在近5年的核心专利中普遍出现;④在专利国别分布上,中国专利数量领先,但主要以制备技术专利为主,结构较为单一,在核心专利、核心研发机构方面还处于空白,水凝胶制备的原创性较低,应集中力量,在具有基础优势的机构中开展原创性研发。BACKGROUND:Hydrogels play an important role in tissue engineering due to their unique flexibility and biocompatibility.Patent is the most important carrier of technical information.Therefore,it has important reference value for research to use patent information metrology to count,extract and compare the information contained in it.OBJECTIVE:To identify and discover hydrogel in tissue engineering technology distribution,research&development focus,trend development,and national competition situation using patent information.METHODS:The Derwent Patent Database as a data source was used to search all patent applications in related fields in the past 30 years.Statistical analysis,community clustering analysis and development path analysis were utilized to conduct research and analysis on the main technology distribution,country advantages,scope of protection,technology path,core patent,and main patentees in the field.RESULTS AND CONCLUSION:The patent analysis of hydrogels in tissue engineering objectively reflects the scale,layout and trend of the patent technology of hydrogels in tissue engineering:(1)Technically,the main research&development fields of hydrogels in tissue engineering are mainly fillers,drug carriers,bio-polymer hydrogels and preparation technologies.Among them,bio-polymer hydrogel technology is the main part.(2)In the focus of research and development,good biocompatibility and degradability are the main goals of the design,and technically using protein/peptide and plant polysaccharides as the main material,metal coordination bond cross-linking and radiation method are the main synthetic process.(3)In the development trend,stem cells and nanotechnology are deeply involved,and nanocellulose and pluripotent stem cells have generally appeared in the core patents in the past 5 years.(4)In terms of country,the number of patents in China is leading,but mainly based on preparation technology patent.The structure is relatively simple.There is still a gap in core patents and core research&development institut

关 键 词：材料 水凝胶 专利分析 专利计量 干细胞 生物相容性 组织工程 填充剂 

分 类 号：R452[医药卫生—治疗学] R456[医药卫生—临床医学]