海南地区HSIL与宫颈癌hr-HPV分布特点及意义  

Characteristics and significance of hr-HPV distribution of HSIL and cervical cancer in Hainan

作　　者：韩一栩 周晖[2] HAN Yixu;ZHOU Hui(Department of Gynecology,Second Affiliated Hospital of Hainan Medical Collegel,Haikou,Hainan 570311,China;Department of Gynecological Oncology,South Branch of Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou,Guangdong 510289,China)

机构地区：[1]海南医学院第二附属医院妇科,海口570311 [2]中山大学孙逸仙纪念医院南院妇科肿瘤专科

出　　处：《公共卫生与预防医学》2020年第6期133-136,共4页Journal of Public Health and Preventive Medicine

摘　　要：目的探讨海南地区宫颈高级别鳞状上皮内病变(HSIL)及宫颈癌(CC)中人乳头瘤病毒(HPV)与高危型HPV感染的特点和意义,为预防HPV感染及宫颈癌筛查提供参考依据。方法选取2017年5月至2019年12月海南医学院第二附属医院妇科住院患者379例(作为病例组),其中HSIL组共220例,CC组共159例。选取同期体检健康女性182例(作为对照组)。采用PCR技术及DNA反向点杂交技术对患者进行HPV-DNA亚型检测,并根据HPV基因型分为13种高危型及10种低危型。分析患者HSIL及CC与高危型HPV感染之间的关系。结果病例组HSIL和CC患者HPV感染率(85.75%)明显高于对照组(26.92%)(P<0.001)。HSIL组中检出HPV高危型感染占94.14%;CC组中检出HPV高危型感染占98.33%。HSIL组中,41~50岁组高危型HPV感染高于其他组;CC组中,>50岁组高危型HPV感染明显高于其他组。病例组和对照组中,单一亚型感染均高于多重感染(P<0.001)。结论该地区HSIL及CC患者以单一亚型、高危型HPV感染为主,且不同年龄段的感染有一定的差异。Objective To explore the characteristics and significance of human papillomavirus(HPV)and high-risk HPV infection in cervical high-grade squamous intraepithelial lesions(HSIL)and cervical cancer(CC)in Hainan,and to provide a reference for the prevention of HPV infection and cervical cancer screening.Methods From May 2017 to December 2019,379 gynecological inpatients in our hospital were selected(as case group),including 220 cases in the HSIL group and 159 cases in the CC group.A total of 182 healthy females undergoing physical examination in the same period of time were selected as a control group.Using PCR technology and DNA reverse dot hybridization technology,the patients were tested for HPV-DNA subtypes which were divided into 13 high-risk types and 10 low-risk types according to HPV genotypes.The relationship between HSIL and CC of patients and high-risk HPV infection was analyzed.Results(1)The HPV infection rate of HSIL and CC patients in the case group(85.75%)was significantly higher than that in the control group(26.92%)(P<0.001).(2)HPV high-risk infections accounted for 94.14%in the HSIL group,while HPV high-risk infections accounted for 98.33%in the CC group.(3)In the HSIL group,the high-risk HPV infections in the 41 to 50-year-old group were higher than those in other age groups;in the CC group,the high-risk HPV infections in the>50-year-old group were significantly higher than those in other age groups.(4)In both the case group and the control group,single subtype infection was higher than multiple infection(P<0.001).Conclusion HSIL and CC patients in this area are mainly infected with single subtype and high-risk HPV.The infection exhibited certain differences in different ages.

关 键 词：宫颈癌 高级别鳞状上皮内病变 HPV 高危型 

分 类 号：R181[医药卫生—流行病学]