肺高压相关肺循环血流动力学计算模拟研究进展  

Research Progress on Computational Hemodynamics of Pulmonary Hypertension

作　　者：王丽平 张明杰 刘金龙 徐卓明[1] WANG Liping;ZHANG Mingie;LIU Jinlong;XU Zhuoming(Department of Thoracic and Cardiovascular Surgery,Shanghai Children's Medical Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China;Shanghai Engineering Research Center of Virtual Reality of Structural Heart Disease,Shanghai 200127,China;Pediatric Translational Medicine Institute,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China)

机构地区：[1]上海交通大学医学院附属上海儿童医学中心心胸外科,上海200127 [2]上海结构性心脏病虚拟现实工程技术研究中心,上海200127 [3]上海交通大学医学院儿科转化医学研究所,上海200127

出　　处：《医用生物力学》2020年第5期497-503,共7页Journal of Medical Biomechanics

基　　金：国家自然科学基金项目(81501558,81771934);上海市科委科技基金项目(17DZ2253100);上海市国际科技合作基金项目(18410721400)。

摘　　要：肺高压(pulmonary hypertension,PH)是由不同病因引起、以肺血管阻力和压力进行性升高为特点的一种致死性疾病,异常血流动力学在其发生发展中具有重要作用。计算流体动力学(computational fluid dynamics,CFD)作为一种新方法应用于临床研究中,可无创获取患者个体化病灶部位三维空间任一点的血流动力学指标,并可通过可视化技术将其呈现,逐渐成为一种可深入了解血流相关疾病进展的有力工具。对近年来CFD应用于肺高压相关肺循环血流动力学研究中涉及的数值模拟方法、边界条件、血液特性以及主要的血流动力学参数进行综合阐述。Pulmonary hypertension( PH) is a devastating disease caused by different etiology and characterized by the progressive elevation of pulmonary vascular resistance and pulmonary artery pressure.As a new method that applied to clinical studies,computational fluid dynamics( CFD) gradually becomes a powerful tool for in-depth understanding of the disease progression.It can noninvasively obtain the patient-specific hemodynamic parameters at any point of the vessel and present them through the visualization technology.In this paper,an overall review of CFD with the focus on PH,including the numerical simulation method,boundary conditions,blood characteristics and relevant hemodynamic parameters was presented.

关 键 词：肺高压 计算流体动力学 血流动力学 

分 类 号：R318.01[医药卫生—生物医学工程]