力学调控长链非编码RNA对间充质干细胞成骨分化作用的研究进展  

Research Advances in the Effect of Mechanical Regulation of Long-Chain Non-Coding RNAs on Osteogenic Differentiation of Mesenchymal Stem Cells

作　　者：程威 林祥龙 张扬 刘洋[1,2] 朱双龙 刘迎节[1] 李瑞欣[4] 徐云强 张西正[2] CHENG Wei;LIN Xianglong;ZHANG Yang;LIU Yang;ZHU Shuanglong;LIU Yingjie;LI Ruixin;XU Yunqiang;ZHANG Xizheng(Department of Orthopaedics,General Hospital of Tianjin Medical University,Tianjin 300052,China;Institute of Medical Support Technology,Academy of System Engineering,Academy of Military Science,Tianjin 300161,China;Tianjin Key Laboratory for Advanced Electromechanical System Design and Inelligent Control,Tanjin University of Technology,Tanjin 300384,China;Central Laboratory,Tanjin Stomatological Hospital,Tianjin 300041,China)

机构地区：[1]天津医科大学总医院骨科,天津300052 [2]军事科学院系统工程研究院,卫勤保障技术研究所,天津300161 [3]天津理工大学天津市先进机电系统设计与智能控制重点实验室,天津300384 [4]天津市口腔医院中心实验室,天津300041

出　　处：《医用生物力学》2020年第5期504-510,共7页Journal of Medical Biomechanics

基　　金：国家自然科学基金项目(31470935,11432016)。

摘　　要：随着第3代高通量测序技术和组织工程的发展,近年来研究发现,许多长链非编码RNA(long-chain noncoding RNAs,LncRNAs)在力学调节间充质干细胞(mesenchymal stem cells,MSCs)的成骨分化中起重要作用。力学因素调控相关的LncRNAs,然后LncRNAs通过转录、转录后以及表观遗传等多层次发挥调节作用,进一步调控骨相关细胞功能。LncRNAs也可能作为力学响应分子参与MSCs成骨分化、骨重建以及骨骼系统疾病的病理过程。With the development of the 3 rd-generation high-throughput sequencing technology and tissue engineering,recent studies show that many long-chain non-coding RNAs( LncRNAs) have played an important role in osteogenic differentiation of mesenchymal stem cells( MSCs).LncRNAs,which are involved in the regulation of mechanical regulation,further regulate bone-related cell functions and play a regulatory role at multiple levels,including transcription,post-transcriptional and epigenetic.LncRNAs may be involved in the osteogenic differentiation and bone remodeling of MSCs,the regulation of bone-related cell functions as a mechanical response molecule,as well as the pathological process of skeletal diseases.

关 键 词：力学调控 长链非编码RNA 骨髓间充质干细胞 成骨分化 

分 类 号：R318.01[医药卫生—生物医学工程]