单原子催化剂的生物医学应用  

Biomedical Applications of Single-atom Catalysts

作　　者：袁中文 贺利贞 陈填烽[1] YUAN Zhongwen;HE Lizhen;CHEN Tianfeng(Department of Chemistry,Jinan University,Guangzhou 510632,China)

机构地区：[1]暨南大学化学系,广州510632

出　　处：《高等学校化学学报》2020年第12期2690-2709,共20页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:21877049,21701051);广东省自然科学基金(批准号:2017A030313051);广州市产业技术重大攻关计划项目(批准号:201902020013);广东省促进经济高质量发展专项资金海洋经济发展项目(批准号:GDOE-2019-A31);广州市分子与功能影像临床转化重点实验室(批准号:201905010003);广东普通高校创新团队项目(批准号:2019KCXTD008)资助.

摘　　要：单原子催化剂(SACs)具有100%的原子利用率及充分暴露的原子金属活性位点,其催化活性和选择性更具优势,已广泛应用在化学、能源及环境等领域.近年来,SACs在生物医学领域也引起了广泛关注.本文综述了SACs在肿瘤治疗、抗菌、抗氧化和生物传感等生物医学领域的应用及研究进展,并简要总结了SACs未来应用的挑战和机遇,为合理设计多性能的SACs提供了可行策略.Single-atom catalysts(SACs),which have 100%atomic utilization and fully exposed atomic metal active sites,show distinct advantages in catalytic activity and selectivity,thus have been widely applied in the fields of chemistry,energy,environment and so on.Since the concept of SACs was proposed,the studies about different monometallic atoms loaded on various supporting materials were reported continuously.As the research of nanozyme has attracted increasing attention,SACs were also explored for their enzyme-like activi⁃ties.Therefore,SACs attract extensive attention in the biomedical domain in recent years,among that,anchoring monatomic metals on nitrogen-doped carbon materials by pyrolysis were the most widespread studied.The M-Nx-C site formed after pyrolysis is similar to the M-Nx site of natural metal enzymes,which endows the mate⁃rials superior enzyme-like activity.Importantly,compared with natural enzymes and nanozymes,SACs own the advantages of simpler synthesis steps,controllable active center and morphology,adjustable coordination environment,better catalytic activity,lower cost,easier commercial application and more convenience to in⁃vest relative catalytic reaction mechanism.It is worth mentioning that,metal atoms with enzyme-like activity(such as Au,Pt,Pd)dispersed on supporting materials(like carbon points,metal oxides,2D material)can also obtain higher enzyme-like activity than nanoparticles or supporting materials themselves.In short,the ex⁃cellent enzyme-like activity is mainly due to the maximum exposure of monodisperse metal atoms in the bioca⁃talysis reaction.Meantime,the strong interaction between these metal atoms and the supporting materials makes the whole system more stable to achieve long-term catalysis.This paper reviews the application and re⁃search progress of SACs in the fields of tumor therapy,antibacterial,antioxidation and biosensor,and some examples will be introduced in detail,including material preparation method,enzyme-like activity,catalytic mechanism and practical a

关 键 词：单原子催化剂 肿瘤治疗 抗菌 抗氧化 生物传感 

分 类 号：O614[理学—无机化学] O643[理学—化学]