参连复脉颗粒治疗室性期前收缩的药效学实验研究  

Pharmacodynamic Experimental Study of Shenlian Fumai Granule in the Treatment of Ventricular Premature Contraction

作　　者：龙佳 鲁婷婷 汪吴娇 逯金金[1] 刘静[1] 任建勋[2] 万洁[1] 林谦 LONG Jia;LU Tingting;WANG Wujiao;LU Jinjin;LIU Jing;REN Jianxun;WAN Jie;LIN Qian(Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078,China)

机构地区：[1]北京中医药大学东方医院,北京100078 [2]中国中医科学院西苑医院 [3]北京中医药大学东直门医院

出　　处：《中西医结合心脑血管病杂志》2020年第22期3775-3779,共5页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：北京市科技计划(No.Z141100002214005);北京中医药大学基本科研业务费基金资助项目(No.2019-JYB-TD008)。

摘　　要：目的研究参连复脉颗粒对室性期前收缩的药效作用及最佳有效药物浓度。方法选取小鼠、豚鼠和大鼠作为研究对象,分别采用氯化钙、哇巴因和乌头原碱诱导动物心律失常模型,观察口服参连复脉颗粒不同剂量组的抗心律失常药效作用。结果实验一:与对照组比较,参连复脉颗粒大剂量组、中大剂量组、中剂量组小鼠心律失常持续时间均有一定程度缩短(P<0.05或P<0.01)。实验二:参连复脉颗粒大剂量组哇巴因诱发室性心律失常的消耗量较对照组显著增加(P<0.05或P<0.01),与美西律组比较差异无统计学意义(P>0.05);参连复脉颗粒中剂量组、小剂量组也能够一定程度增加哇巴因的消耗量。同时参连复脉颗粒各剂量组心律失常出现时间均有一定程度延长,与对照组比较差异有统计学意义(P<0.05或P<0.01)。实验三:与对照组比较,参连复脉颗粒大剂量组、中剂量组大鼠心律失常持续时间均有一定程度缩短(P<0.05或P<0.01)。提示大、中剂量组与阳性对照药(胺碘酮或美西律)在心律失常出现时间或缩短持续时间程度有相同的作用趋势,差异无统计学意义(P>0.05)。结论参连复脉颗粒大、中剂量组对氯化钙、哇巴因、乌头原碱引起的室性期前收缩均有一定的拮抗作用,与胺碘酮或美西律作用相似,中剂量为最低起效剂量。Objective To research the pharmacodynamic effect of Shenlian Fumai Granule on ventricular premature contraction(VPC)and the optimal effective drug concentration.Methods The arrhythmia induced by calcium chloride,ouabain,and aconitine in mice,guinea pigs,and rats were used to observe the anti-arrhythmia effect of oral Shenlian Fumai Granule in different dose groups.Results Experiment 1:Compared with the control group,the duration of arrhythmia in mice with different doses of Shenlian Fumai Granule was shortened to some extent(P<0.05 or P<0.01).Experiment 2:The consumption of ouabain-induced ventricular arrhythmia in large dose groups of Shenlian Fumai Granule was significantly increased(P<0.05 or P<0.01),but there was no statistically significant difference compared with mexiletine group(P>0.05),and the consumption of ouabain-induced ventricular arrhythmia in medium and small groups of Shenlian Fumai Granule were increased to some extent.Compared with control group,the occurrence time of arrhythmias was prolonged to a certain extent in different doses groups of Shenlian Fumai Granule(P<0.05 or P<0.01).Experiment 3:Compared with the control group,the duration of arrhythmia in large and medium dose groups of Shenlian Fumai Granule was shortened to some extent(P<0.05 or P<0.01).The three experiments suggested that the effect of large and medium dose groups had the same trend with positive control drugs(amiodarone or mexiletine)in the occurrence time or shortened duration of arrhythmia,but there was no statistical difference(P>0.05).Conclusion The large and medium dose group of Shenlian Fumai Granule had certain antagonistic effect on VPC caused by calcium chloride,ouabain,and aconitine,which was similar to the action of amiodarone or mexiletine,and the medium dose was the lowest effective dose.

关 键 词：室性期前收缩 参连复脉颗粒 药效学 实验研究 药物浓度 

分 类 号：R541.7[医药卫生—心血管疾病] R256.2[医药卫生—内科学]