子宫恶性中胚叶混合瘤临床病理特点、鉴别诊断及预后分析  

Clinicopathological features,differential diagnosis and prognosis of malignant mixed mesodermal tumor of uterus

作　　者：刘小宁 崔丽燕 亢姝娇 张立君 LIU Xiaon-ing;CUI Li-yan;KANG Shu-jiao;ZHANG Li-jun(Inner Mongolia maternal and child health care hospital,Neimenggu Huhehaote 010010,China)

机构地区：[1]内蒙古自治区妇幼保健院,内蒙古呼和浩特010010

出　　处：《临床医药文献电子杂志》2020年第78期4-5,共2页Electronic Journal of Clinical Medical Literature

摘　　要：目的探究子宫恶性中胚叶混合瘤临床病理特点、鉴别诊断及预后分析。方法选取2009年4月~2019年4月我院收治的子宫恶性中胚叶混合瘤患者10例。结果本研究中存在4例恶性上皮成分ER检测为阳性;2例恶性上皮成分PR检测为阳性;3例desmin检测为阳性;1例S100检测为阳性;本研究存在9例SALL4呈阳性,8例OCT3/4呈弥漫性细胞核阳性,6例CD117呈阳性,1例Glypican-3呈灶性表达。术后实施化疗的患者预后效果优于未实施化疗的患者(P<0.05)。结论子宫恶性中胚叶混合瘤疾在诊断时利用比较先进的检查方法辅助诊断,能够提高诊断率,同时利用免疫组织化学染色对肿瘤进行辅助诊断,或者使用基因检测都极大提高该肿瘤的诊断率,同时具有理想效果。Objective To explore the clinicopathological features,differential diagnosis and prognosis of malignant mesodermal mixed tumor of uterus.Methods A total of 10 patients with uterine malignant mesoblastoma admitted to our hospital from April 2009 to April 2019 were selected.Results In this study,4 cases of malignant epithelial component ER were positive.Two cases of malignant epithelial components were positive for PR.Desmin test was positive in 3 cases.1 case of S100 tested positive;In this study,9 patients were positive for SALL4,8 for oct3/4 for diffuse nucleus,6 for CD117,and 1 for focal expression of glypican-3.The prognosis of patients who received chemotherapy was better than those who did not(P<0.05).Conclusion The diagnosis of uterine malignant mesenchymal mixed tumor can be improved by using advanced examination methods,and the diagnosis rate can be greatly improved by immunohistochemical staining or gene testing.

关 键 词：子宫恶性中胚叶混合瘤 临床病理特点 鉴别诊断 

分 类 号：R44[医药卫生—诊断学]