2型糖尿病患者血清Fetuin B水平与并发下肢动脉粥样硬化性病变的相关性研究  

Relationship between Serum Fetuin B Level and Atherosclerotic Lesions in Lower Limb of Patients with Type 2 Diabetes Mellitus

作　　者：陈树鑫 宁晔[1] 韩登科 CHEN Shu-xin;NING Ye;HAN Deng-ke(Emergency Care Center,Zhongshan Hospital Affiliated to Sun Yat-Sun University,Guangdong Zhongshan 528403,China;Laboratory Medicine Center,Zhongshan Hospital Affiliated to Sun Yat-Sun University,Guangdong Zhongshan 528403,China)

机构地区：[1]中山大学附属中山医院急救中心,广东中山528403 [2]中山大学附属中山医院检验医学中心,广东中山528403

出　　处：《现代检验医学杂志》2020年第6期21-24,47,共5页Journal of Modern Laboratory Medicine

基　　金：广东省中山市医学科研基金项目(2019J040)。

摘　　要：目的探讨血清中胎球蛋白(Fetuin B)水平与2型糖尿病(T2DM)患者下肢动脉粥样硬化性病变(LEAD)的关系。方法选取2018年7月~2019年3月,中山大学附属中山医院内分泌科治疗的122例T2MD患者作为研究对象,分为T2DM组和LEAD组,其中T2DM组患者41例,LEAD组81例。选取同时期45例健康体检者作为对照组。分析LEAD患者血清Fetuin B,血压、肝肾功能、血脂、血糖、尿酸和Hcy水平变化情况。结果对照组、T2DM组和LEAD组血清中Fetuin B水平呈逐渐升高趋势,血清中Fetuin B水平分别是9.384±5.014,55.700±37.902和58.752±69.377 ng/ml,LEAD组与对照组和T2DM组比较,差异有统计学意义(F=13.962,P<0.05);二元logistic回归分析,Fetuin B和TG是LEAD患者的独立危险因素。ROC曲线结果,血清中Fetuin B在19.639 ng/ml时,对LEAD患者具有较好的诊断价值(AUC 0.835,灵敏度0.700,特异度0.977)。TG在1.375mmol/L时,具有较好的诊断价值(AUC 0.773,灵敏度0.625,特异度0.841)。结论血清中Fetuin B升高可能会使T2DM患者增加双下肢动脉粥样硬化的风险,监测血清中Fetuin B水平的变化情况,有助于早发现T2DM病患者双下肢动脉粥样硬化病变的发生,为临床早诊断早治疗提供一定的依据。Objective To investigate the relationship between serum Fetuin B level and atherosclerotic lesions(LEAD)of lower limb in patients with type 2 diabetes mellitus(T2DM).Methods From July 2018 to March 2019,122 cases of T2MD patients treated by endocrine therapy in Zhongshan Hospital Affiliated to Sun Yat-sen University were divided into T2DM group and LEAD group,including 41 cases in T2DM group and 81 cases in LEAD group.During the same period,45 healthy subjects were selected as the control group.The changes of serum Fetuin B,blood pressure,liver and kidney function,blood lipid,blood glucose,uric acid and Hcy levels in the LEAD patient were analyzed.Results The serum Fetuin B level in the control group,the T2DM group and the LEAD group showed a gradually increasing trend.The serum Fetuin B level was 9.384±5.014,55.700±37.902 and 58.752±69.377 ng/ml,respectively.The difference between the LEAD group and the control group and the T2DM group was statistically significant(F=13.962,P<0.05).Binary logistic regression analysis,Fetuin B and TG were independent risk factors for LEAD patients.ROC curve results:when serum Fetuin B was 19.639 ng/ml,it had good diagnostic value for the LEAD patient(AUC 0.835,sensitivity 0.700,specificity 0.977),and when TG was 1.375 mmol/L,it had better diagnostic value(AUC 0.773,sensitivity 0.625,specific degrees 0.841).Conclusion Higher serum Fetuin B may lead to T2DM increases the risk of double lower extremity atherosclerosis,monitoring the change of serum Fetuin B level,help to early detection in patients with T2DM of double lower limbs artery atherosclerotic lesions,provide a basis for clinical early diagnosis and treatment.

关 键 词：2型糖尿病 下肢动脉粥样硬化性病变 胎球蛋白B 

分 类 号：R587.1[医药卫生—内分泌] R543.5[医药卫生—内科学]