支气管哮喘患儿CXCL5和IL-29水平及意义  

Levels and significance of CXCL5 and IL-29 in children with bronchial asthma

作　　者：赵晓辉 Zhao Xiao-hui(Department of Clinical Laboratory,The People's Hospital of Linyin,Luohe 462600,Henan,China)

机构地区：[1]临颍县人民医院检验科,河南漯河462600

出　　处：《四川生理科学杂志》2020年第4期456-459,464,共5页Sichuan Journal of Physiological Sciences

摘　　要：目的:探讨支气管哮喘患儿血清CXCL5和IL-29水平及意义。方法:选取2016年1月至2019年1月212例支气管患儿作为哮喘组,并依据疾病的严重程度分为间歇组(n=50)、轻度组(n=51)、中度组(n=49)、重度组(n=46),选择同期参加体检的50例健康儿童作为对照组,采用酶联免疫吸附法检测血清CXCL5和IL-29水平,肺功能仪检测肺功能,包括第1秒用力呼气量(Forced expiratory volume in 1 second,FEV 1)、用力肺活量(Forced vital capacity,FVC)和FEV1/FVC,并进行统计学分析。结果:哮喘组患儿血清CXCL5和IL-29水平明显高于对照组(P<0.05),并随患儿哮喘严重程度的加重逐渐增加,且与FEV1、FVC、FEV1/FVC等肺功能指标呈现负相关(P<0.05),而CXCL5与IL-29呈现明显的正相关(P<0.05)。结论:CXCL5和IL-29参与了支气管哮喘的发生和进展,促进了机体的炎症反应,可以作为评估哮喘诊断和严重程度的指标。Objective:To investigate the serum levels of CXCL5 and IL-29 in children with bronchial asthma and their significance.Methods:Two hundred and twelve cases of bronchial children(asthma group)from January 2016 to January 2019 were divided into intermittent group(n=50),mild group(n=51),moderate group(n=49)and severe group(n=46),according to the severity of the disease.Fifty healthy children participated in the physical examination at the same time were selected as the control group.The serum CXCL5 and IL-29 levels were measured by ELISA.The spirometer measures lung function,including forced expiratory volume in 1 second(FEV 1),forced vital capacity(FVC)and FEV1/FVC and statistical analysis was performed.Results:The serum levels of CXCL5 and IL-29 in asthmatic group were significantly higher than those in control group(P<0.05),and increased gradually with the severity of asthma,and negatively correlated with FEV1,FVC,FEV1/FVC(P<0.05),while CXCL5 and IL-29 were positively correlated(P<0.05).Conclusion:CXCL5 and IL-29 are involved in the occurrence and progression of bronchial asthma,and promote the body's inflammatory response.It can be used as an indicator to assess the diagnosis and severity of asthma.

关 键 词：支气管哮喘 儿童 CXCL5 IL-29 相关性 

分 类 号：R725.6[医药卫生—儿科]