101例年轻宫颈癌患者的临床病理因素及其预后分析  

Analysis of Clinicopathological Factors and Prognosis of 101 Young Cervical Cancer Patients

作　　者：袁风玲 贾淑慧[2] 江源[3] YUAN Fengling;JIA Shuhui;JIANG Yuan(The First People's Hospital of Xining,Xining,810000)

机构地区：[1]青海省西宁市第一人民医院,810000 [2]青海省中医院,810000 [3]南京市鼓楼医院,210008

出　　处：《实用癌症杂志》2020年第12期2058-2060,2086,共4页The Practical Journal of Cancer

基　　金：青海省科技厅基金项目(编号:9632011Y0141)。

摘　　要：目的探讨101例年轻宫颈癌患者的临床病理因素及其预后。方法选择101例宫颈癌患者,分析其临床病理特征,病理类型与预后的关系,术后高危病理因素与预后的关系及年轻宫颈患者的预后影响因素。结果101例年轻宫颈癌患者中,其中鳞癌者占86.1%,非鳞癌者占13.9%。年轻宫颈癌患者中低分化鳞癌者占78.2%;鳞癌患者淋巴结转移阴性者占72.3%,早期宫颈癌鳞癌患者的中位生存期明显长于非鳞癌患者(P<0.05)。脉管浸润阴性患者的中位生存期明显长于阳性患者(P<0.05);宫颈间质浸润<1/2患者的中位生存期明显长于≥1/2患者(P<0.05)。COX多因素回顾分析表明:淋巴结转移、病理类型与患者预后密切相关(P<0.05)。结论早期宫颈癌非鳞癌、脉管浸润阳性、宫颈间质浸润≥1/2宫颈癌患者的中位生存期较低,淋巴结转移者预后较差,对此类患者需积极给予辅助治疗及严密随访。Objective To investigate the clinicopathological factors and prognosis of 101 young women with cervical cancer.Methods 101 patients with cervical were selected,who were following-up by telephone and outpatient follow-up,the starting point was the diagnosis time,the follow-up time was 20~68 months.The clinicopathological features,pathological types and prognosis of 101 young cervical cancer patients,the relationship between high-risk pathological factors and prognosis after surgery,and the prognostic factors of young cervical cancer patients were analyzed.Results Among 101 young patients with cervical cancer,squamous cell carcinoma accounted for 86.1%and non-squamous cell carcinoma 13.9%.The proportion of low differentiated squamous cell carcinoma in young women with cervical cancer was 78.2%.The proportion of patients with squamous cell carcinoma with negative lymph node metastasis was 72.3%,and the median survival time of patients with early cervical squamous cell carcinoma was significantly longer than that of patients without squamous cell carcinoma(P<0.05).The median survival time of patients with negative vascular infiltration was significantly longer than that of patients with positive vascular infiltration(P<0.05).The median survival time of patients with cervical interstitial infiltration<1/2 was significantly longer than that of patients with cervical interstitial infiltration≥1/2(P<0.05).COX multivariate retrospective analysis showed that the lymph node metastasis and pathological type were closely related to patients'prognosis(P<0.05).Conclusion Patients with early cervical cancer with non-squamous cell carcinoma,positive vascular infiltration and cervical interstitial infiltration≥1/2 have a low median survival period,and poor prognosis in patients with lymph node metastasis.Therefore,active adjuvant therapy and strict follow-up are required for such patients.

关 键 词：年轻宫颈癌 病理因素 预后 中位生存期 COX回归分析 

分 类 号：R737.33[医药卫生—肿瘤]