慢性心力衰竭患者血清可溶性细胞间黏附分子-1和半乳糖凝集素-3的表达及其临床意义  

Expression and clinical significance of serum soluble intercellular adhesion molecule-1 and galactosan-3 in patients with chronic heart failure

作　　者：王剑锋 凌华 WANG Jian-feng;LING hua(Department of Cardiology,Chun’an Branch of the First People’s Hospital of Hangzhou(Chun’an County Hospital of Traditional Chinese Medicine),Hangzhou,Zhejiang 311700,China)

机构地区：[1]杭州市第一人民医院淳安分院(淳安县中医院)心内科,浙江杭州311700

出　　处：《中华全科医学》2020年第12期2040-2042,2143,共4页Chinese Journal of General Practice

基　　金：浙江省医学会临床科研基金项目(2019ZYC-A17)。

摘　　要：目的分析慢性心力衰竭患者血清可溶性细胞间黏附分子-1(soluble intercellular adhesion molecule-1,sICAM-1)、半乳糖凝集素-3(galectin 3)的表达及其临床意义。方法选择2016年3月—2019年3月杭州市第一人民医院淳安分院收治的452例慢性心力衰竭患者,根据NYHA分级法将其分为NYHAⅡ级组(151例)、NYHAⅢ级组(164例)、NYHAⅣ级组(137例),根据随访3个月内是否发生主要不良心血管事件(MACE)分为MACE组及非MACE组,另选取同期在我院体检者73例作为对照组,分别测定并比较各组血清sICAM-1和galectin 3水平。结果慢性心力衰竭组血清sICAM-1水平为(771.08±186.54)μg/L、galectin 3水平为(21.26±4.35)ng/mL均明显高于对照组(均P<0.05)。NYHAⅣ级组和NYHAⅢ级组血清sICAM-1、galectin 3表达水平明显高于NYHAⅡ级组(均P<0.05),NYHAⅣ级组明显高于NYHAⅢ级组(P<0.05)。MACE组入院次日和出院当日血清sICAM-1、galectin 3表达水平明显高于非MACE组(P<0.05),非MACE组出院当日血清sICAM-1、galectin 3表达水平明显低于入院次日(P<0.05)。慢性心力衰竭患者血清sICAM-1与galectin 3呈显著正相关(r=0.671,P=0.004)。结论血清sICAM-1、galectin 3表达水平与慢性心力衰竭患者心功能及预后有关。Objective To analyze the expression and clinical significance of serum soluble intercellular adhesion molecule-1(sICAM-1)and galectin-3 in patients with chronic heart failure.Methods A total of 452 patients of with chronic heart failure admitted to Chun’an Branch of the First People’s Hospital of Hangzhou from March 2016 to March 2019 were divided into NYHAⅡgroup(151 cases),NYHAⅢgroup(164 cases),and NYHAⅣgroup(137 cases)according to NYHA classification.According to the occurrence of major adverse cardiovascular events(MACE)during the follow-up period,the patients were divided into MACE group and non-MACE group,another 73 cases of physical examination in our hospital during the same period were selected as the control group.The serum levels of sICAM-1 and galectin-3 were measured.Results The expression levels of sICAM-1 in the chronic heart failure group was(771.08±186.54)μg/L and galectin-3 was(21.26±4.35)ng/mL,there were significantly higher than those in the control group(all P<0.05).The expression levels of sICAM-1 and galectin-3 in the NYHA gradeⅣand NYHA gradeⅢgroups were significantly higher than those in the NYHA gradeⅡgroup(all P<0.05),and that in the NYHA gradeⅣgroup was significantly higher than that in the NYHA gradeⅢgroup(P<0.05).The expression levels of sICAM-1 and galectin-3 in the MACE group on the next day of admission and the day of discharge were significantly higher than those of the non-MACE group(P<0.05).The expression of sICAM-1 and Galectin-3 on the day of discharge in the non-MACE group was significantly lower than that on the day after admission(P<0.05).There was a significant positive correlation between sICAM-1 and galectin-3 in patients with chronic heart failure(r=0.671,P=0.004).Conclusion The expression of sICAM-1 and galectin-3 in serum is related to the cardiac function and prognosis in patients with chronic heart failure.

关 键 词：慢性心力衰竭 可溶性细胞间黏附分子-1 半乳糖凝集素-3 

分 类 号：R541.6[医药卫生—心血管疾病] R446[医药卫生—内科学]