血流变学检验在心血管疾病诊断中的临床价值  

Clinical value of hemorheology test in the diagnosis of cardiovascular diseases

作　　者：徐怡娜[1] 袁海军[1] 胡益飞 赵栋[2] XU Yi-na;YUAN Hai-jun;HU Yi-fei;ZHAO Dong(Department of Laboratory Medicine,Jinhua Central Hospital,Jinhua,Zhejiang 321000,China;不详)

机构地区：[1]金华市中心医院检验科,浙江金华321000 [2]金华市中心医院麻醉科

出　　处：《中华全科医学》2020年第12期2075-2077,共3页Chinese Journal of General Practice

基　　金：浙江省医药卫生科技计划项目(2019RC301)。

摘　　要：目的分析血流变学检验在心血管疾病诊断中的应用价值,探讨血流变学指标与心血管疾病发生与发展的相关性。方法选取金华市中心医院2019年6月—2020年6月收治的62例心血管疾病患者纳入研究组,同时选取同时期行常规体检的62例健康志愿者纳入对照组,2组均应用全自动血液流变分析仪进行全血高切黏度、全血低切黏度、血浆黏度、红细胞聚集指数、红细胞刚性指数、红细胞变形指数、红细胞压积、血沉、血浆纤维蛋白原等血流变学指标检验,比较2组受试者的检验结果,应用Pearson相关性分析法分析血流变学指标与心血管疾病的相关性。结果研究组治疗前的全血高切黏度、全血低切黏度、红细胞聚集指数、红细胞刚性指数、红细胞变形指数、红细胞压积、血浆纤维蛋白原检验水平均高于对照组(均P<0.05),血沉检验水平低于对照组(P<0.05);研究组治疗前的血浆黏度与对照组比较无差异(P>0.05)。研究组治疗后的上述指标与对照组相比差异均无统计学意义(均P>0.05)。研究组治疗后的全血高切黏度、全血低切黏度、红细胞聚集指数、红细胞刚性指数、红细胞变形指数、红细胞压积、血浆纤维蛋白原检验水平均低于治疗前,血沉检验水平高于治疗前(均P<0.05);血浆黏度与治疗前比较无差异(P>0.05)。Pearson相关性分析显示,心血管疾病与全血高切黏度、全血低切黏度、红细胞聚集指数、红细胞刚性指数、红细胞变形指数、红细胞压积、血浆纤维蛋白均呈正相关,与血沉呈负相关,与血浆黏度无相关性。结论血流变学指标在心血管疾病中呈异常状态,血流变学检验可作为临床诊断心血管疾病的辅助参考依据,对提高诊断结果的准确率具有重要意义。Objective To analyze the application value of hemorheology test in the diagnosis of cardiovascular diseases,and to explore the correlation between hemorheology indexes and the occurrence and development of cardiovascular diseases.Methods A total of 62 cases of cardiovascular disease patients in our hospital from June 2019 to June 2020 were selected and included in the study group.Meanwhile,62 healthy volunteers who underwent routine physical examination in our hospital at the same time were selected as the control group.The whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity,erythrocyte aggregation index,erythrocyte rigidity index,red blood cell fineness index were measured by automatic hemorheology analyzer.The hemorheology indexes such as cell deformation index,hematocrit,erythrocyte sedimentation rate,plasma fibrinogen were compared between the two groups.Pearson correlation analysis method was used to analyze the correlation between hemorheology indexes and cardiovascular disease.Results Before treatment,the whole blood high shear viscosity,whole blood low shear viscosity,erythrocyte aggregation index,erythrocyte rigidity index,erythrocyte deformation index,hematocrit and plasma fibrinogen test levels of the study group were higher than those of the control group,and the ESR test level was lower than that of the control group(P<0.05).The plasma viscosity of the study group before treatment was similar to that of the control group(P>0.05).After treatment,the above indexes in the study group were compared with those in the control group(all P>0.05).After treatment,the whole blood high shear viscosity,whole blood low shear viscosity,erythrocyte aggregation index,erythrocyte rigidity index,erythrocyte deformation index,hematocrit and plasma fibrinogen test levels in the study group were lower than those before treatment,and the ESR test level was higher than that before treatment(P<0.05).The plasma viscosity was similar to that before treatment(P>0.05).Pearson correlation analysis sh

关 键 词：血流变学检验 心血管疾病 诊断 临床价值 

分 类 号：R446[医药卫生—诊断学] R54[医药卫生—临床医学]