唐山市7~13岁超重肥胖儿童尿酸水平及影响因素分析  

Preliminary analysis on distribution characteristics and risk factors of uric acid in overweight and obese children aged 7-13 in Tangshan City

作　　者：陈新春[1] 谷小娜 寇永妹[1] 杨振朋[1] 杨雪冰[1] CHEN Xinchun;GU Xiaona;KOU Yongmei;YANG Zhenpeng;YANG Xuebing(Department of Pediatrics Tangshan Municipal People’s Hospital,Tangshan(063001),Hebei Province,China)

机构地区：[1]河北省唐山市人民医院儿科,063001

出　　处：《中国学校卫生》2020年第11期1695-1698,共4页Chinese Journal of School Health

基　　金：河北省2019年度医学科学研究课题项目(20191599)。

摘　　要：目的探讨唐山市超重肥胖儿童尿酸分布特征及影响因素,为预防儿童高尿酸血症及其相关疾病提供参考。方法以2018—2019年唐山市543名超重、肥胖学龄儿童为研究对象,选取同期正常体重儿童503名为对照组,测量身高、体重、腰围(waist circumference,WC)和血压(BP),计算体质量指数(BMI)、腰围身高比(waist-to-height ration,WHtR);留取血标本测得尿酸(serum-uric acid,UA)、空腹血糖(fasting blood glucose,FPG)、总胆固醇(tatal cholesterol,TC)、三酰甘油(triglyceride,TG)、高密度脂蛋白胆固醇(high density lipoprotein-cholesterol,HDL-C)、低密度脂蛋白胆固醇(low density liporotein-cholesterol,LDL-C)。以年龄分组描述尿酸水平分布特征,分析尿酸与相关指标的关系。结果体重正常组、超重肥胖组儿童尿酸水平分别为(278.15±89.68,322.72±89.50)μmol/L,差异有统计学意义(t=-8.04,P<0.01)。体重正常组、超重肥胖组高尿酸血症检出率分别为11.33%,23.94%,差异有统计学意义(χ^2=28.28,P<0.01)。UA水平与年龄、BMI、体重、TC、LDL-C呈正相关(r值分别为0.12,0.17,0.28,0.14,0.23,P值均<0.01),与HDL-C呈负相关(r=-0.25,P<0.01)。多因素Logistic回归分析显示,年龄、BMI、WHtR、TC、LDL-C是高尿酸血症的影响因素[OR值(OR值95%CI)分别为0.82(0.72~0.94)、1.13(1.08~1.18)、0.38(0.23~0.64)、6.79(2.15~21.44)、0.04(0.01~0.14)]。结论唐山市超重肥胖儿童尿素水平、高尿酸检出率高于体重正常儿童;年龄、肥胖、血脂紊乱是肥胖超重儿童高尿酸血症的影响因素。Objective To describe the distribution characteristics of uric acid and associated factors among overweight and obese children in Tangshan City,so as to provide reference for the prevention of childhood hyperuricemia and related diseases.Methods A total of 543 overweight and obese school-age children in Tangshan from 2018 to 2019 were selected,503 children of normal weight were selected as the control group.Height,weight,waist circumference(WC),blood pressure(BP)were measured,then the Body mass index(BMI)and waist-to-height ratio(WHtR)were calculated.Uric acid(UA),fasting blood glucose(FPG),total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol(LDLC)were measured.The distribution characteristics of uric acid level were described by age groups,and the relationship between uric acid and related indicators were analyzed.Results The mean uric acid of normal weight group,overweight and obese group were(278.15±89.68,322.72±89.50)μmol/L respectively,the difference was statistically significant(t=-8.04,P<0.01).The detection rates of hyperuricemia in normal weight group,overweight and obesity group were 11.33% and 23.94%respectively,with statistically significant difference(χ^2=28.28,P<0.01).UA level was positively correlated with age,BMI,body weight,TC,LDL-C(r=0.12,0.17,0.28,0.14,0.23,P<0.01),and negatively correlated with HDL-C(r=-0.25,P<0.01).Age,BMI,WHtR,TC,LDL-C were the influencing factors of hyper-uricemia[OR(95%CI)=0.82(0.72-0.94),1.13(1.08-1.18),0.38(0.23-0.64),6.79(2.15-21.44),0.04(0.01-0.14)].Conclusion The urea level and high uric acid detection rate of overweight and obese children in Tangshan were higher than those of normal weight children.Age,obesity and dyslipidemia were influencing factors of hyperuricemia in obese and overweight children.

关 键 词：超重 肥胖症 尿酸 回归分析 儿童 

分 类 号：R723.14[医药卫生—儿科] R446[医药卫生—临床医学]