β肾上腺素能受体阻滞剂治疗创面的作用机制及在糖尿病足溃疡中的应用前景  

Mechanisms of adrenergicβ-antagonist for wounds and its application prospect in diabetic foot ulcers

作　　者：孙世怡 马婧 冉兴无[1] SUN Shiyi;MA Jing;RAN Xingwu(Diabetic Foot Care Center,Department of Endocrinology and Metabolism,West China Hospital,Sichuan University,Chengdu Sichuan,610041,P.R.China;Department of Endocrinology and Metabolism,Gansu Provincial Hospital,Lanzhou Gansu,730000,P.R.China)

机构地区：[1]四川大学华西医院内分泌与代谢科糖尿病足诊治中心,成都610041 [2]甘肃省人民医院内分泌与代谢科,兰州730000

出　　处：《中国修复重建外科杂志》2020年第12期1630-1634,共5页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：重大新药创制专项资金资助项目(2017ZX09304023);成都市科技局产业技术研究院技术创新项目(2017-CY02-00028-GX);四川健康医疗大数据应用创新工程项目(2018gfgw001);四川大学华西医院学科卓越发展1·3·5工程项目(ZYGD18025)。

摘　　要：目的总结近年来β肾上腺素能受体(以下简称β受体)阻滞剂治疗创面,尤其是糖尿病慢性皮肤溃疡的研究进展,探讨其在糖尿病足溃疡(diabetic foot ulcer,DFU)的应用前景。方法广泛查阅国内外有关β受体阻滞剂治疗创面和糖尿病慢性皮肤溃疡的文献,总结分析β受体阻滞剂在创面修复过程中的作用机制及其用于治疗DFU的前景。结果β受体阻滞剂能促进创面愈合,其可能作用机制包括加速再上皮化、促进创面血管形成、改善神经病变、调节炎症反应和生长因子等。目前,临床研究结果显示,β受体阻滞剂可作为一种治疗糖尿病慢性皮肤溃疡的辅助手段。结论β受体阻滞剂能够促进糖尿病慢性皮肤溃疡修复,但仍需大样本的多中心随机对照试验以及长期随访进一步验证其疗效及安全性。Objective To review the research progress of adrenergicβ-antagonists on wounds and diabetic chronic cutaneous ulcers healing in recent years,and to investigate its application prospect in diabetic foot ulcer(DFU).Methods The latest literature about the role of adrenergicβ-antagonists in wounds and diabetic chronic cutaneous ulcers healing was extensively reviewed,and the mechanisms of adrenergicβ-antagonists for wounds and its potential benefit for DFU were analyzed thoroughly.Results The adrenergicβ-antagonists can accelerate the wound healing.The possible mechanisms include accelerating re-epithelialization,promoting angiogenesis,improving neuropathy,and regulating inflammation and growth factors,etc.At present clinical research data showed that the adrenergicβ-antagonists may be an adjuvant treatment for diabetic chronic cutaneous ulcers.Conclusion Adrenergicβ-antagonists maybe promote the healing of wounds and diabetic chronic cutaneous ulcers.However,more long-term follow-up and high-quality randomized control studies are needed to further verify their efficacy and safety for DFU.

关 键 词：Β肾上腺素能受体阻滞剂 糖尿病足 溃疡 创面愈合 作用机制 

分 类 号：R587.2[医药卫生—内分泌]