超声检查联合基因及血清检测预测甲状腺微小乳头状癌的侵袭性  

Application of Ultrasound Examination Combined with BRAF V600E Gene and Serum TSH in Predicting PTMC Aggressiveness

作　　者：刘威 彭梅[1] 姜凡[1] 王圣应 刘建军[2] 陶堃 何杰[4] Liu Wei;Peng Mei;Jiang Fan;Wang Shengying;Liu Jianjun;Tao Kun;He Jie(Department of Ultrasound,the Second Hospital of Anhui Medical University,Anhui,Hefei 230601,China;Department of Head and Neck,Ultrasound,Pathology the First Affiliated Hospital of USTC West District,Anhui,Hefei 230601,China)

机构地区：[1]安徽医科大学第二附属医院超声科,合肥市230601 [2]中国科学技术大学附属第一医院西区头颈乳腺外科 [3]中国科学技术大学附属第一医院西区超声科 [4]中国科学技术大学附属第一医院西区病理科

出　　处：《中国超声医学杂志》2020年第12期1071-1074,共4页Chinese Journal of Ultrasound in Medicine

基　　金：安徽省重点研究与开发计划项目(No.201904a07020068)。

摘　　要：目的旨在通过超声检查联合BRAF V600E基因以及血清TSH预测PTMC结节的侵袭性,为评估PTMC侵袭能力提供一定的参考依据。方法收集经手术病理证实的194例单灶PTMC患者,根据病灶是否突破甲状腺被膜或有无发生淋巴结转移,将PTMC分为侵袭组和惰性组。对侵袭组与惰性组之间的超声特征、BRAF V600E基因、血清TSH以及临床因素进行Student′s t或Chisquare检验,再采用Logistic回归筛选PTMC侵袭性的危险因素。结果男性,BRAF V600E基因突变型、肿瘤最大径>6mm、边缘不光整、微钙化、US-LNM以及血清TSH均是PTMC侵袭性的危险因素。结论超声检查联合BRAF V600E基因以及血清TSH能够为评估PTMC侵袭能力提供一定的参考依据。Objective This study aimed to predict the aggressiveness of PTMC nodules through ultrasound examination combined with BRAF V600Egene and serum TSH,and provide a reference for evaluation of PTMC aggression ability.Methods 194patients with unifocal PTMC confirmed by pathology were enrolled,divided into aggressive group and indolent group according to whether the lesion being extrathyroidal extensions or clinical lymph node metastasis.Student′s t or Chi-square test was performed on the ultrasonic characteristics,BRAF V600Egene,serum TSH as well as clinical factors between aggressive group and indolent group.Logistic regression analysis was used to screen the risk factors of PTMC aggressiveness.Results Male,BRAFV600Egene mutation,tumor largest size>6mm,US-LNM,ill-defined border,microcalcification and serum TSH were associated with aggressiveness.Conclusions Ultrasound examination combined with BRAF V600Egene and serum TSH may provide a reference for evaluation of PTMC aggression ability.

关 键 词：甲状腺微小乳头状癌 超声检查 BRAF V600E基因 血清TSH 侵袭性 

分 类 号：R445.1[医药卫生—影像医学与核医学] R736.1[医药卫生—诊断学]