聚苯乙烯@聚(N-异丙基丙烯酰胺)核壳球的纳米化制备  

Nanofabrication of polystyrene@poly(N-isopropylacrylamide)core-shell spheres

作　　者：肖新才[1] 谭宏飞 王振环 官亚兰 XIAO Xincai;TAN Hongfei;WANG Zhenhuan;GUAN Yalan(School of Pharmaceutical Sciences,South-Central University for Nationalities,Wuhan 430074,China;Hangzhou HezePharmaceutical Technology Co.,Ltd.,Hangzhou 310018,China;Hainan Poly Pharmaceutical Co.,Ltd.,Haikou 570100,China)

机构地区：[1]中南民族大学药学院,武汉430074 [2]杭州和泽医药科技有限公司,杭州310018 [3]海南普利制药股份有限公司,海口570100

出　　处：《中南民族大学学报（自然科学版）》2020年第6期614-618,共5页Journal of South-Central University for Nationalities：Natural Science Edition

基　　金：国家自然科学基金资助项目(21978329);中央高校基本科研业务费专项资金资助项目(CZP20004)。

摘　　要：以四氢呋喃(THF)和水为反应介质,制备了具有聚苯乙烯核-交联聚(N-异丙基丙烯酰胺)壳的纳米球,研究了水中的搅拌速率、N-异丙基丙烯酰胺浓度和苯乙烯的反应时间等因素对球体尺寸和单分散性的影响.结果表明:在一定条件下,可以得到平均粒径为63 nm,单分散性较好的纳米球.同时,苯乙烯在THF中的聚合时间为第一影响因素,其次是在水环境聚合下的搅拌速度.该方法在疏水性药物的输送、油-水分离、单分子检测、胶体科学等具有较高的吸引力.Nanospheres with polystyrene cores and crosslinked poly(N-isopropylacrylamide)shells were fabricated using tetrahydrofuran and water as reaction media.The effect of reaction conditions,including stirring rates in water,N-isopropylacrylamide concentration and styrene reaction time on the size and monodispersity of the spheres were investigated.The results showed that a mean diameter of 63 nm with good monodispersity could be obtained under certain condition.Moreover,the polymerization time of styrene in THF was the prominent influencing factor,followed by the stirring speed for polymerization in water environment.The proposed protocol was highly attractive for hydrophobic-drug delivery,oil-water separation,single molecule detection,colloid science and so on.

关 键 词：纳米制备 两亲性结构 良溶剂 不良溶剂 

分 类 号：O632.13[理学—高分子化学]