The Release Behavior,Biocompatibility and Physical Properties of Aid-loaded Strontium Doped Calcium Phosphate Cement  

作　　者：Maryam Mohammadi Sayed Mahmood Rabiee Saeed Hesaraki 

机构地区：[1]Department of Materials Engineering,Babol Noshirvani University of Techmology,Babol 71167-47148,Iran [2]Nanotechnologv and Advanced Materials,Materials and Energy Research Center,Karaj 3177983634,Alborz,Iran

出　　处：《Journal of Bionic Engineering》2020年第6期1209-1223,共15页仿生工程学报（英文版）

基　　金：Iran National Science Foundation(INSF)for the research under Grant No.96015802.

摘　　要：The effect of concurrent attendance of two inhibitors of bone degradation,namely Alendronate(Aid)sodium trihydrate and Strontium(Sr),on Calcium Phosphate Cement(CPC)characteristics was explored.To this aim,5 wt%Strontium and 21 mM Alendronate sodium trihydrate were used in calcium phosphate cement and setting time,ion and drug release were analyzed.RAW264.7 and G cell were cultured on cement samples and Tartrate-Resistant Acid Phosphatase(TRAP),Alkaline phosphatase(ALP)activity and MTT assay were studied.The results of structural analysis indicated that 21 mM Aid did not let the cement set.Therefore,colloidal silica was added to the cement formula and successfully decreased the setting time.In vitro tests showed Sr-loaded sample had a greater inhibitory effect on biocompatibility of G cells than Aid-loaded and Sr-Ald-loaded samples.In addition,the findings about osteoblast MTT and ALP activity indicated that Sr was more effective in osteogenic activity of G cells.The simultaneous presence of Aid and Sr in Calcium Phosphate Cement(CPC)was not as effective in its biocompatibility as the presence of Sr alone.

关 键 词：calcium phosphate cements drug release alendronate sodium trihydrate STRONTIUM RAW264.7 cell G cell 

分 类 号：TQ172.1[化学工程—水泥工业]