动脉血管壁主动和被动力学性能实验测量和建模分析  

Experimental measurement and modeling analysis of active and passive mechanical properties of arterial vessel wall

作　　者：冯韵迪 吴昊(综述) 霍云龙(审校) FENG Yundi;WU Hao;HUO Yunlong(PKU-HKUST Shenzhen-HongKong Institution,Shenzhen,Guangdong 518057,P.R.China;Institute of Mechanobiology&Medical Engineering,School of Life Sciences&Biotechnology,Shanghai Jiao Tong University,Shanghai 200240,P.R.China)

机构地区：[1]深港产学研基地,广东深圳518057 [2]上海交通大学生命科学技术学院力学生物学研究所,上海200240

出　　处：《生物医学工程学杂志》2020年第6期939-947,共9页Journal of Biomedical Engineering

基　　金：深圳市科创委孔雀团队计划(KQTD20180411143400981)。

摘　　要：心血管疾病(CAD)已经严重威胁着人类健康。对血管壁力学性质的实验测量和建模分析可以为疾病的诊断、支架的植入,以及人工血管的设计等提供理论依据。动脉血管壁有主动和被动的力学性能,被动力学性能主要由弹性纤维和胶原蛋白纤维的含量和结构决定;主动力学性能则由平滑肌细胞(VSMC)的收缩实现。大量研究表明,动脉血管壁的双层膜结构模型可以很好地反映血管的力学性能,血管壁的周向、轴向、径向应力都有重要作用。本文综述了近年来血管壁力学性质测量和力学性能建模方面的研究进展,以及该研究方向面临的挑战和机遇,以期为临床心血管疾病的治疗提供支持。Coronary artery diseases(CAD)have always been serious threats to human health.The measurement,constitutive modeling,and analysis of mechanical properties of the blood vessel wall can provide a tool for disease diagnosis,stent implantation,and artificial artery design.The vessel wall has both active and passive mechanical properties.The passive mechanical properties are mainly determined by elastic and collagen fibers,and the active mechanical properties are determined by the contraction of vascular smooth muscle cells(VSMC).Substantial studies have shown that,the two-layer model of the vessel wall can feature the mechanical properties well,and the circumferential,axial and radial strain and stress are of great significance in arterial wall mechanics.This study reviewed recent investigations of mechanical properties of the vessel wall.Challenges and opportunities in this area are discussed relevant to the clinical treatment of coronary artery diseases.

关 键 词：心血管力学 应力和应变 血管壁本构模型 血管壁主动力学性质 血管壁被动力学性质 

分 类 号：R318[医药卫生—生物医学工程]