生物可降解聚合物支架构型设计与力学性能研究  

Design and mechanical properties of biodegradable polymeric stent

作　　者：陈宇[1] 王冠石[1] 陈冲[1] 孙安强[2] 冯文韬(综述) 蒋文涛(审校)[1] CHEN Yu;WANG Guanshi;CHEN Chong;SUN Anqiang;FENG Wentao;JIANG Wentao(Department of Mechanical Science and Engineering,Sichuan University,Chengdu 610065,P.R.China;School of Biological Science and Medical Engineering,Beihang University,Beijing 100191,P.R.China)

机构地区：[1]四川大学力学科学与工程系,成都610065 [2]北京航空航天大学生物与医学工程学院,北京100191

出　　处：《生物医学工程学杂志》2020年第6期967-973,共7页Journal of Biomedical Engineering

基　　金：科技部国家重点研发计划项目(2017YFB0702500);国家自然科学基金面上项目(11772210);四川省科技厅国际合作项目(2018HH0073)。

摘　　要：生物可降解支架是经皮冠状动脉介入治疗(PCI)的一个里程碑,其中生物可降解聚合物支架由于其生物相容性好、降解速度适中、降解产物无毒副作用受到普遍关注,但是由于聚合物材料力学性能较差,影响了聚合物支架的临床应用。本文从支架构型设计入手,分析通过构型设计来提高聚合物支架的径向支撑力、柔顺性,以及减小回缩率。此外,本文还以支架数值模拟、体外实验和动物实验等结果为依据,详细介绍聚合物支架的构型设计对结果的影响和相关力学性能研究,以期对今后聚合物支架的研究发展提供参考。Biodegradable stents(BDSs)are the milestone in percutaneous coronary intervention(PCI).Biodegradable polymeric stents have received widespread attention due to their good biocompatibility,moderate degradation rate and degradation products without toxicity or side effects.However,due to the defects in mechanical properties of polymer materials,the clinical application of polymeric BDS has been affected.In this paper,the BDS geometric configuration design was analyzed to improve the radial strength,flexibility and reduce the shrinkage rate of biodegradable polymeric stents.And from the aspects of numerical simulation,in vitro experiment and animal experiment,the configuration design and mechanical properties of biodegradable polymeric stents were introduced in detail in order to provide further references for the development of biodegradable polymeric stents.

关 键 词：生物可降解 聚合物 支架 构型 力学性能 

分 类 号：R318.08[医药卫生—生物医学工程]