血流动力学优化在人工心脏设计中的应用  

Application of hemodynamic optimization in the design of artificial heart

作　　者：符珉瑞 高斌[1] 常宇[1] 刘有军[1] FU Minrui;GAO Bin;CHANG Yu;LIU Youjun(Faculty of Environment and Life,Beijing University of Technology,Beijing 100124,P.R.China)

机构地区：[1]北京工业大学环境与生命学部,北京100124

出　　处：《生物医学工程学杂志》2020年第6期1000-1011,共12页Journal of Biomedical Engineering

基　　金：国家自然科学基金(61931013,11832003,81701644);国家重点研发计划(2017YFC0111104);山西省重点研发计划(201803D421005);北京市教委青年拔尖人才培育计划(CIT&TCD201904025);北京工业大学日新人才项目(015000514118002);武汉市卫健委计划(WX18A01)。

摘　　要：心力衰竭(心衰)是一种高危险、高发病率的心血管疾病。人工心脏作为心力衰竭的有效治疗手段正逐步应用于临床治疗中。血液相容性是人工心脏的重要参数或者指标,而如何通过血流动力学设计与体外溶血实验对其进行评价是业内的研究热点。本文首先对人工心脏血流动力学优化以及体外溶血评价方面的研究进展进行综述,之后介绍团队在相关领域的研究成果与进展。本文中所优化的血泵,血流动力学性能满足使用需求,体外溶血实验获得的溶血指数小于0.1 g/100 L,有较好的体外溶血性能。本文所述的优化方法适合于大部分血泵的开发工作,能够为相关研究工作提供借鉴。Heart failure is one kind of cardiovascular disease with high risk and high incidence.As an effective treatment of heart failure,artificial heart is gradually used in clinical treatment.Blood compatibility is an important parameter or index of artificial heart,and how to evaluate it through hemodynamic design and in vitro hemolysis test is a research hotspot in the industry.This paper first reviews the research progress in hemodynamic optimization and in vitro hemolysis evaluation of artificial heart,and then introduces the research achievements and progress of the team in related fields.The hemodynamic performance of the blood pump optimized in this paper can meet the needs of use.The normalized index of hemolysis obtained by in standard vitro hemolysis test is less than 0.1 g/100 L,which has good hemolysis performance in vitro.The optimization method described in this paper is suitable for most of the development of blood pump and can provide reference for related research work.

关 键 词：血流动力学 心室辅助装置 优化 溶血 归一化溶血指数 

分 类 号：R318.11[医药卫生—生物医学工程]