丁苯酞对外伤性蛛网膜下腔出血患者脑循环及血清炎症因子水平的影响  

Effects of N-Butylphthalide on cerebral circulation and serum inflammatory factors in patients with traumatic subarachnoid hemorrhage

作　　者：金鹏[1] 蒋文庆[1] 蒋蔚[1] 魏文峰[1] 武洪林[2] JIN Peng;JIANG Wen-qing;JIANG Wei(Department of Neurosurgery, Wujin Hospital Affiliated with Jiangsu University, The Wujin Clinical College of Xuzhou Medical University, Changzhou 213017, China)

机构地区：[1]江苏大学附属武进医院,徐州医科大学武进临床学院神经外科,常州213017 [2]江苏大学附属武进医院,徐州医科大学武进临床学院影像科,常州213017

出　　处：《临床神经外科杂志》2020年第6期700-703,共4页Journal of Clinical Neurosurgery

基　　金：武进科技支撑计划(WS201815,WS201805);江苏大学临床医学科技发展基金(JLY20180085,JLY20180087);常州市应用基础研究计划(CJ20180006)。

摘　　要：目的探讨丁苯酞对外伤性蛛网膜下腔出血(tSAH)患者脑循环和血清炎症因子水平的影响。方法将58例外伤性蛛网膜下腔出血患者随机分为丁苯酞注射液治疗组(丁苯酞组,28例)和对照组(30例)。两组患者均给予蛛网膜下腔出血常规治疗;丁苯酞组患者在常规治疗的基础上加用丁苯酞注射液治疗,连续10 d。两组患者治疗前后进行脑CT灌注成像,以及血清白细胞介素(IL)-1β、IL-6、肿瘤坏死因子α(TNFα)水平检测。结果与对照组相比,丁苯酞组患者的脑血流量(CBF)及脑血容量(CBV)水平显著提高,平均通过时间(MTT)显著降低(均P<0.05)。丁苯酞组患者在治疗后5 d和10 d的血清IL-1β、IL-6、TNFα水平均显著低于对照组(均P<0.05)。两组患者并发症发生率的差异无统计学意义(均P>0.05)。结论丁苯酞注射液可有效改善外伤性蛛网膜下腔出血患者的脑循环状况,降低血清炎症因子水平,减轻迟发性脑损伤。Objective To observe the effects of N-Butylphthalide on cerebral circulation and serum inflammatory factors in patients with traumatic subarachnoid hemorrhage(tSAH).Methods 58 patients with tSAH were randomly divided into experimental group(28 cases)and control group(30 cases).Patients in the control group were given conventional treatment,while patients in the experimental group were administered additional N-Butylphthalide injection.The changes of cerebral circulation and serum inflammatory factors(Il-1β,IL-6 and TNFα)levels before and after treatment were compared between the two groups.Results Compared with the control group,the cerebral blood flow(CBF)and cerebral blood volume(CBV)of the experimental group were significantly improved and the mean transmit time(MTT)was significantly decreased(P<0.05).The serum levels of IL-1β,IL-6 and TNFαin the experimental group were significantly lower than those in the control group at 5 and 10 days after treatment(P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusion N-Butylphthalide can effectively improve the cerebral circulation,reduce the level of serum inflammatory factors and reduce the delayed brain injury in patients with tSAH.

关 键 词：外伤性蛛网膜下腔出血 丁苯酞 脑循环 炎症因子 

分 类 号：R651.1+5[医药卫生—外科学]