北京地区25家医院晚期早产儿住院期间母乳喂养对感染相关性疾病发生的影响  

Effect of breastfeeding on the development of infection-related diseases during hospitalization in late preterm infants in 25 hospitals in Beijing,China

作　　者：韩露艳 徐小静 童笑梅[2] 张欣[3] 刘捷[4] 杨立 刘慧 闫菊[7] 宋志芳 梅亚波 米荣[10] 秦选光[11] 刘玉环 齐宇洁[13] 张巍[14] 曾慧慧[14] 崔红[15] 龙卉 郭果 陈旭琳 杨召意 孙芳[20] 付晓辉 王长燕[22] 李正红[22] HAN Lu-Yan;XU Xiao-Jing;TONG Xiao-Mei;ZHANG Xin;LIU Jie;YANG Li;LIU Hui;YAN Ju;SONG Zhi-Fang;MEI Ya-Bo;MI Rong;QIN Xuan-Guang;LIU Yu-Huan;QI Yu-Jie;ZHANG Wei;ZENG Hui-Hui;CUI Hong;LONG Hui;GUO Guo;CHEN Xu-Lin;YANG Zhao-Yi;SUN Fang;FU Xiao-Hui;WANG Chang-Yan;LI Zheng-Hong(Department of Pediatrics,First Hospital of Tsinghua University,Beijing 100016,China)

机构地区：[1]清华大学第一附属医院儿科,北京100016 [2]北京大学第三医院儿科,北京100191 [3]北京大学第一医院儿科,北京100034 [4]北京大学人民医院儿科,北京100871 [5]北京市通州区妇幼保健院儿科,北京101101 [6]北京市大兴区人民医院儿科,北京102600 [7]北京医院儿科,北京100730 [8]北京市延庆县医院儿科,北京102100 [9]中国人民解放军总医院第七医学中心儿科,北京100710 [10]首都儿科研究所附属儿童医院儿科,北京100191 [11]首都医科大学附属北京朝阳医院儿科,北京100043 [12]首都医科大学附属北京地坛医院儿科,北京100015 [13]首都医科大学附属北京儿童医院儿科,北京100045 [14]首都医科大学附属北京妇产医院儿科,北京100026 [15]首都医科大学附属北京友谊医院儿科,北京100050 [16]中国人民解放军总医院第一医学中心儿科,北京100853 [17]中国人民解放军总医院第五医学中心,北京100039 [18]中国人民解放军总医院第三医学中心,北京100101 [19]中国人民解放军总医院第六医学中心儿科,北京100048 [20]中日友好医院儿科,北京100029 [21]北京上地医院,北京100193 [22]中国医学科学院北京协和医学院北京协和医院儿科,北京100730

出　　处：《中国当代儿科杂志》2020年第12期1245-1250,共6页Chinese Journal of Contemporary Pediatrics

摘　　要：目的了解北京地区晚期早产儿住院期间感染性疾病的发生率,分析感染性疾病发生的危险因素,探讨母乳喂养对感染性疾病发生的影响。方法收集北京地区25家医院新生儿病房在2015年10月23日至2017年10月30日住院的晚期早产儿资料。根据喂养方式分为母乳喂养组和配方奶喂养组,比较两组一般情况、感染性疾病的发生率,并应用多因素logistic回归分析感染性疾病发生的危险因素。结果纳入1576例晚期早产儿,其中母乳喂养组153例,配方奶喂养组1423例。发生感染性疾病共计484例(30.71%),其中母乳喂养组感染性疾病发生率显著低于配方奶喂养组(22.88%vs 31.55%,P=0.033)。多因素logistic回归分析显示,母乳喂养是感染性疾病发生的独立保护性因素(OR=0.534,P=0.004),而男婴、胎膜早破、妊娠糖尿病、窒息是发生感染性疾病的危险因素(分别OR=1.328、5.386、1.535、2.353,均P<0.05)。结论母乳喂养可降低晚期早产儿住院期间感染性疾病的发生,是晚期早产儿感染性疾病的保护因素,应积极提倡晚期早产儿住院期间实施母乳喂养。Objective To investigate the incidence rate of infectious diseases during hospitalization in late preterm infants in Beijing,China,as well as the risk factors for infectious diseases and the effect of breastfeeding on the development of infectious diseases.Methods Related data were collected from the late preterm infants who were hospitalized in the neonatal wards of 25 hospitals in Beijing,China,from October 23,2015 to October 30,2017.According to the feeding pattern,they were divided into a breastfeeding group and a formula feeding group.The two groups were compared in terms of general status and incidence rate of infectious diseases.A multivariate logistic regression analysis was used to investigate the risk factors for infectious diseases.Results A total of 1576 late preterm infants were enrolled,with 153 infants in the breastfeeding group and 1423 in the formula feeding group.Of all infants,484(30.71%)experienced infectious diseases.The breastfeeding group had a significantly lower incidence rate of infectious diseases than the formula feeding group(22.88%vs 31.55%,P=0.033).The multivariate logistic regression analysis showed that breastfeeding was an independent protective factor against infectious diseases(OR=0.534,P=0.004),while male sex,premature rupture of membranes,gestational diabetes mellitus,and asphyxia were risk factors for infectious diseases(OR=1.328,5.386,1.535,and 2.353 respectively,P<0.05).Conclusions Breastfeeding can significantly reduce the incidence of infectious diseases and is a protective factor against infectious diseases in late preterm infants.Breastfeeding should therefore be actively promoted for late preterm infants during hospitalization.

关 键 词：母乳喂养 感染 晚期早产儿 

分 类 号：R722.6[医药卫生—儿科]