莪术醇及其衍生物的抗肿瘤活性研究进展  

Research progress on anti-tumor activity of curcumol and its derivatives

作　　者：聂添情 孟祥伟 应宇晨 张兴贤[1] NIE Tian-qing;MENG Xiang-wei;YING Yu-chen;ZHANG Xing-xian(College of Pharmaceutical Sciences,Zhejiang University of Technology,Hangzhou 310014,China)

机构地区：[1]浙江工业大学药学院,浙江杭州310014

出　　处：《中草药》2020年第21期5613-5621,共9页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(21372203);浙江中医药大学省重点建设高校优势特色学科(中药学)开放基金资助项目(ZYAOXZD2019008);浙江省新苗人才计划项目(2019R403044)。

摘　　要：莪术醇作为莪术Curcuma rhizoma的重要成分,具有抗病毒、抗炎、抗肿瘤等药理活性,在抗肿瘤研究领域受到了广泛关注。通过查阅近年来国内外相关文献,综述了莪术醇的天然来源、抗肿瘤作用机制及其结构修饰、抗肿瘤活性评价等方面的研究进展,为其进一步的结构优化策略提供新的研究思路。Curcumol,as an important component of Curcuma Rhizoma,has anti-virus,anti-inflammatory,anti-tumor and other pharmacological activities,which has attracted more and more attentions in anti-tumor research area.The progress on the natural source,anti-tumor mechanism,structural modification,and anti-tumor evaluation of curcumol are reviewed in this paper,which will provide a novel strategy for its further structural optimization.

关 键 词：莪术 莪术醇 天然来源 抗肿瘤机制 结构修饰 抗肿瘤活性 

分 类 号：R282.71[医药卫生—中药学]