中药毒性的研究现状及其超分子“印迹模板”调控机制的探讨  

Research status and regulatory mechanism based on supramolecular“imprinted template”of toxicity of Chinese materia medica

作　　者：贺玉婷 樊启猛 周逸群[1,2] 李海英 贺鹏 王敏存 周燕子 潘雪 孟蕾[1,2] 贺福元 HE Yu-ting;FAN Qi-meng;ZHOU Yi-qun;LI Hai-ying;HE Peng;WANG Min-cun;ZHOU Yan-zi;PAN Xue;MENG Lei;HE Fu-yuan(College of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China;Hunan Provincial Key Laboratory of Drugability and Preparation Modification of TCM,Changsha 410208,China;Supramolecular Mechanism and Mathematic-Physics Chracterization for Chinese Materia Medica,Hunan University of Chinese Medicine,Changsha 410208,China)

机构地区：[1]湖南中医药大学药学院,湖南长沙410208 [2]中药成药性与制剂制备湖南省重点实验室,湖南长沙410208 [3]湖南中医药大学中医药超分子机理与数理特征化实验室,湖南长沙410208

出　　处：《中草药》2020年第21期5638-5644,共7页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81573691);国家自然科学基金资助项目(81703824,81874507);国家自然科学基金资助项目(81874507);湖南省科技厅重点实验室建设资助项目(2016TP1017);湖南省自然科学基金资助项目(2016JJ4065);湖南省教育厅创新平台开放基金项目(18K071);湖南省“国内一流培育学科”药学2018年开放基金项目(2018YX06);湖南省研究生科研创新项目(CX20190570);湖南中医药大学研究生科研创新课题(2018CX18)。

摘　　要：基于前期提出的中医药超分子“印迹模板”自主作用规律,分析中药毒性的研究现状,结合超分子“气析”理论,阐述中药毒性的超分子“印迹模板”的调控机制:中药(客体超分子)可与人体(主体超分子)发生作用,中药成分群与机体内对应的孔穴通道进行识别,有毒中药的量效问题、减毒处理都与平衡常数及浓度密切相关,当具有相同(似)“印迹模板”药物的浓度相同时,毒性的大小取决于其与靶点作用的平衡常数。因此,提出了中药毒性的平衡常数研究思路,可用超分子印迹作用的平衡常数表征中药毒性,通过研究平衡常数的大小可判断成分产生毒性的主客体分子间作用程度,揭示毒性效应的主客体超分子间相互作用,促进中医药超分子体系及中药毒性的研究。Based on the universal regularity of the automatic action of supramolecular“imprinted template”previously proposed,this paper further analyzed and summarized the historical evolution and research status of the toxicity of Chinese materia medica,and deeply analyzed the production of toxicity of Chinese materia medica by using the theory of supramolecular chemistry.After entering the human body,the aggregation of supramolecular“imprinted template”of Chinese materia medica can interact with the similar“imprinted template”of the subject supramolecular of human in the human body.In other words,the group of toxic components of Chinese materia medica can be identified with the corresponding hole channels in the body,which is the supramolecular chemical mechanism of the toxicity of Chinese materia medica.The dose-effect problem and detoxification treatment of toxic Chinese materia medica is closely related to the equilibrium constant and concentration.When the concentration of the drug with the same(similar to)imprinted template is the same,the toxicity depends on the equilibrium constant of its interaction with the target.Based on this,research idea of equilibrium constant of toxicity of Chinese materia medica was proposed.The equilibrium constant of supramolecular imprinted behavior can explain the toxicity of Chinese materia medica.By studying the equilibrium constant,the supramolecular interaction of the toxic effect can be revealed and the supramolecular system of Chinese materia medica can be well studied.

关 键 词：中药毒性 超分子化学 气析 印迹作用 平衡常数 网络毒效动力学 

分 类 号：R285.1[医药卫生—中药学]