强心2号方治疗慢性心力衰竭39例  

Thirty-Nine Cases of Chronic Heart Failure Treated with No.2 Formula for Strengthening Heart

作　　者：裴雯 李颖 PEI Wen;LI Ying(Jing′an District Hospital of TCM of Shanghai,Shanghai,China,200072)

机构地区：[1]上海市静安区中医医院,上海200072

出　　处：《河南中医》2020年第12期1887-1891,共5页Henan Traditional Chinese Medicine

基　　金：上海市静安区卫生科研课题项目(2013QN04)。

摘　　要：目的:观察强心2号方治疗慢性心力衰竭的临床疗效。方法:将81例慢性心力衰竭患者按照随机数字表法分为治疗组39例和对照组42例。对照组在治疗原发病基础上口服马来酸依那普利叶酸片、倍他乐克片,治疗组在对照组的基础上加服强心2号方。比较两组患者中医证候疗效、心功能疗效及治疗前后中医证候积分、左室功能、心率变异[记录24 h内正常R-R间期的标准差(standard deviation of normol R-R intervals,SDNN)、24 h内连续每5 min正常R-R间期的标准差(standard deviation of 5 min average normol R-R intervals,SDANN)及24 h内相邻R-R间期差值的均方根(square root of the mean of the squared differences between adjacent normal R-R intervals,rMSSD)]情况,检测两组患者治疗前后N末端脑钠肽前体(N-terminal pro brain natriuretic peptide,NT-proBNP)水平。结果:中医证候疗效:对照组有效率为31.0%,治疗组有效率为89.7%,两组患者有效率比较,差异具有统计学意义(P<0.05)。心功能疗效:对照组有效率为69.0%,治疗组有效率为82.1%,两组患者有效率比较,差异无统计学意义(P>0.05)。两组患者治疗后中医证候积分及NT-proBNP低于本组治疗前,且治疗组治疗后低于对照组治疗后,差异具有统计学意义(P<0.05)。两组患者治疗后心功能级别改善例数多于治疗前,且治疗组治疗后多于对照组治疗后,差异具有统计学意义(P<0.05)。治疗组治疗后左室功能各指标均低于本组治疗前及对照组治疗后,差异具有统计学意义(P<0.05);对照组治疗后左室功能各指标低于本组治疗前,仅LVEDD与治疗前比较,差异具有统计学意义(P<0.05)。治疗组治疗后SDNN、SDANN、rMSSD均高于本组治疗前及对照组治疗后,差异具有统计学意义(P<0.05);对照组治疗后心率变异各指标高于本组治疗前,仅rMSSD与治疗前比较,差异具有统计学意义(P<0.05)。结论:强心2号方治疗慢性心力衰竭,可明显改善患者临床Objective:To observe the clinical curative effect of No.2 Formula for Strengthen Heart on chronic heart failure(CHF).Methods:A total of 81 patients with CHF were divided into the treatment group and control group according to random number table method,with 42 cases in each group.The control group was given Enalapril Maleate Folic Acid Tablets and Betaloc Tablets for oral administration on the basis of the treatment of primary diseases,while the treatment group was additionally given No.2 Formula for Strengthening Heart on the basis of the control group.The TCM syndrome efficacy,cardiac function efficacy,TCM syndrome score,left ventricular function and heart rate variability before and after the treatment were compared between the two groups,and the levels of N-terminal pro brain natriuretic peptide(NT-proBNP)before and after treatment were detected.Results:TCM syndrome efficacy:the effective rate of the control group was 31.0%,and that of the treatment group was 89.7%.The difference between the two groups was statistically significant(P<0.05).Cardiac function efficacy:the effective rate of the control group was 69.0%,and that of the treatment group was 82.1%.There was no significant difference between the two groups(P>0.05).After the treatment,TCM syndrome score and NT proBNP of the two groups were lower than those of the same group before the treatment,and the above indexes of the treatment group was lower than those of the control group after the treatment,and all the differences were statistically significant(P<0.05).After the treatment,the number of cases of cardiac function improvement in the two groups was more than that before the treatment,and the number of the treatment group was more than that of the control group after the treatment,and the difference was statistically significant(P<0.05).After the treatment,the indexes of left ventricular function in the treatment group were lower than those before the treatment and those in the control group after the treatment,and all the differences were statistic

关 键 词：慢性心力衰竭 强心2号方 阴中求阳法 马来酸依那普利叶酸片 倍他乐克片 

分 类 号：R259.414[医药卫生—中西医结合]