化浊益髓方治疗脑小血管病认知障碍  

Clinical Observation of Huazhuo Yisui Recipe in Treating Cognitive Impairment of Patients with Cerebral Small Vessel Disease

作　　者：李鑫[1] 吴君璇 朱巍明 刘伟[4] 李雅慧[4] 田财军[1] LI Xin;WU Junxuan;ZHU Weiming;LIU Wei;LI Yahui;TIAN Caijun(The Affiliated Hospital to Shandong University of Chinese Medicine,Ji′nan Shandong China 250000;Guangzhou University of Chinese Medicine,Guangzhou Guangdong China 510000;Shandong University of Chinese Medicine,Ji′nan Shandong China 250000;The Second Affiliated Hospital to Shandong University of Chinese Medicine,Ji′nan Shandong China 250000)

机构地区：[1]山东中医药大学附属医院,山东济南250000 [2]广州中医药大学,广东广州510000 [3]山东中医药大学,山东济南250000 [4]山东中医药大学第二附属医院,山东济南250000

出　　处：《中医学报》2020年第12期2666-2671,共6页Acta Chinese Medicine

基　　金：山东省中医药科技发展计划项目(2017-051)。

摘　　要：目的:观察化浊益髓方对脑小血管病患者认知障碍的改善作用。方法:收集符合纳入标准的72例病例,随机分为对照组和治疗组,各36例。两组患者均给予常规西药内科基础治疗,治疗组患者同时给予化浊益髓方。在治疗前、治疗后14天、治疗后90天对两组患者各进行一次日常生活能力量表、美国国立卫生研究院卒中量表、简易精神状态量表、蒙特利尔认知评估量表、汉密尔顿抑郁量表评分。结果:与对照组比较,治疗组各项评分在治疗后14天无明显差异;治疗组治疗90天与治疗14天NIHSS评分比较差异有统计学意义(P<0.05),治疗组治疗90天与治疗14天HAMD评分比较差异有显著统计学意义(P<0.01),治疗组治疗90天与治疗14天MMSE评分、MoCA评分比较差异有显著统计学意义(P<0.01),两组药物均未对患者血常规、尿常规、肝功能、肾功能造成损伤。结论:化浊益髓方可明显改善脑小血管病患者认知障碍,且不增加服药风险。Objective:To observe the effect of Huazhuo Yisui Recipe on the cognitive impairment of patients with cerebral small vessel disease.Methods:Collect 72 cases that meet the inclusion criteria and randomly divide them into a control group and a treatment group,with 36 cases in each.Patients in both groups were given basic medical treatment with conventional western medicine,and patients in the treatment group were given Huazhuo Yisui Recipe at the same time.Before treatment,14 days after treatment,and 90 days after treatment,the two groups of patients were given a daily ability scale,National Institutes of Health Stroke Scale,Simple Mental State Scale,Montreal Cognitive Assessment Scale,Hamilton Depression Scale score.Results:Compared with the control group,there was no significant difference in the scores of the treatment group at 14 days after treatment;the NIHSS scores of the treatment group were significantly different between 90 days of treatment and 14 days of treatment(P<0.05).The comparison of HAMD scores at 14 days of treatment was statistically significant(P<0.01),and the differences in MMSE scores and MoCA scores between 90 days of treatment and 14 days of treatment in the treatment group were statistically significant(P<0.01).Cause damage to patients′blood routine,urine routine,liver function,and kidney function.Conclusion:Huazhuo Yisui Recipe can significantly improve the cognitive impairment of patients with cerebral small vessel disease without increasing the risk of medication.

关 键 词：脑小血管病 认知障碍 化浊益髓方 

分 类 号：R259[医药卫生—中西医结合]