临床常见耐药细菌及其天然抗生素增效剂的研究进展  

Research progress on common clinical resistant bacteria and their natural synergist for antibiotics

作　　者：曹珍 薛璇玑 张新新[1] 詹冠群 郭增军[1] CAO Zhen;XUE Xuan-ji;ZHANG Xin-xin;ZHAN Guan-qun;GUO Zeng-jun(Shaanxi Key Laboratory of“Qiyao”Resources and Anti-tumor Activities,Shaanxi Traditional Chinese Medicine Extracts Engineering Technology Research Center,School of Pharmacy,Xi’an Jiaotong University,Xi’an 710061,China)

机构地区：[1]西安交通大学药学院陕西中药提取物工程技术研究中心陕西省中医药管理局"七药"资源及抗肿瘤重点研究室,陕西西安710061

出　　处：《中草药》2020年第22期5868-5876,共9页Chinese Traditional and Herbal Drugs

基　　金：陕西省中医药管理局第四次“全国中药资源普查”项目(财社[2018]43号);2020年陕西省重点研发计划项目(2020ZDLSF05-05);陕西省中医药优秀中青年科技骨干人才。

摘　　要：近年来,细菌耐药性已经发展成为一个全球性的问题,以临床常见耐药细菌及其天然抗生素增效剂为研究对象,通过查阅国内外相关文献,对国内外各种天然产物与临床中常使用的抗生素联合使用以降低各种细菌的耐药性及产生作用的机制等进行归纳、分析,总结了临床中常见的耐药细菌及降低其耐药性的天然抗生素增效剂的相关研究。研究表明,天然产物由于其结构的复杂性和新颖性,可作为抗生素增效剂,为降低各种细菌的耐药性以及为临床治疗各种病菌引起的感染提供治疗思路。In recent years, drug-resistant bacteria have developed into a global problem. Common clinically resistant bacteria and their natural antibiotic synergists are the objects of research in this paper. Through consulting the relevant literature at home and abroad, the combination of various natural products and antibiotics commonly used in clinic to reduce the various bacterial drug resistance and the mechanism of action are summarized and analyzed. The related studies on the common drug-resistant bacteria in clinical practice and the natural antibiotic synergists to reduce their resistance were summarized in this paper. The results show that natural products can be used as antibiotic synergists due to their structural complexity and novelty, which provides new ideas and methods for clinical treatment of drug-resistant bacterial infections.

关 键 词：细菌 耐药性 天然产物 抗生素 协同作用 作用机制 

分 类 号：R286.81[医药卫生—中药学]