天麻素生物合成的研究进展  

Research progress on biosynthesis of gastrodin

作　　者：徐德宏[1,2] 崔培梧[1,2] 罗怀浩[1] 罗月芳 江灵敏 谭朝阳[1,2] XU De-hong;CUI Pei-wu;LUO Huai-hao;LUO Yue-fang;JIANG Ling-min;TAN Chao-yang(Laboratory of Biological Engineering,College of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China;Laboratory of Biotransformation,College of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China)

机构地区：[1]湖南中医药大学药学院生物工程实验室,湖南长沙410208 [2]湖南中医药大学生物转化实验室,湖南长沙410208

出　　处：《中草药》2020年第22期5877-5883,共7页Chinese Traditional and Herbal Drugs

基　　金：湖南省自然科学基金资助项目(2019JJ50444);湖南中医药大学生物工程重点学科资助项目(校行科字[2018]3号)。

摘　　要：天麻素是我国名贵中药材天麻中的一种主要活性成分,具有降血压、抗癫痫、抑制肿瘤、保护神经等多方面的药理活性。随着市场对天麻素需求的不断增长以及传统获取方法固有的问题,导致急需新的方法来解决天麻素生产实际中面临的各项困难。生物合成法是一种有别于传统获取法的新方法,已在天麻素获取上取得了较大进展和成果,故现阶段有必要从天麻素生物合成途径、植物转化法和微生物转化法3个方面,对天麻素生物合成进行系统地阐述,从而为进一步改进和完善天麻素生产方法,以满足人们对其不断增长的需求提供有价值的参考。Gastrodin is a major active ingredient in Gastrodia elata,which is one of the traditional rare medicinal herbs in China.It has lots of pharmacological activities,such as reducing blood pressure,anti-epileptic,anti-tumor,and protecting nerve,etc.With the increasing demand for gastrodin in the market and the inherent problems of traditional methods on obtaining gastrodin,new methods are urgently needed to solve various difficulties in the actual production of gastrodin.Biosynthesis is a new method instead of the traditional acquisition method,and has made great progress and achievements in gastrodin acquisition.Therefore,it is necessary to systematically review the biosynthesis of gastrodin from three aspects of biosynthetic pathway,plant transformation and microbial transformation in this paper,hoping to provide valuable reference for further improvement and perfection of gastrodin production method in the future to meet public increasing demand for gastrodin.

关 键 词：天麻素 生物合成 植物转化 微生物转化 野生菌转化法 工程菌转化法 

分 类 号：R284.3[医药卫生—中药学]