黑果枸杞化学成分和药理活性的研究进展  

Research progress on chemical constituents and pharmacological activities of Lycium ruthenicum

作　　者：马丽娟 霍鹏超 孙梦茹 朱亮 胡情 葛广波 贾守宁[1] MALi-juan;HUO Peng-chao;SUN Meng-ru;ZHU Liang;HU Qing;GE Guang-bo;JIA Shou-ning(Qinghai Hospital of Traditional Chinese Medicine,Xining 810000,China;Institute of Interdisciplinary Integrative Medicine Research,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]青海省中医院,青海西宁810000 [2]上海中医药大学交叉科学研究院,上海201203

出　　处：《中草药》2020年第22期5884-5893,共10页Chinese Traditional and Herbal Drugs

基　　金：青海省重点研发和转化科技合作专项(2019-HZ-819);2018年中医药公共卫生服务补助专项“全国中药资源普查项目”(财社〔2018〕43号)。

摘　　要：黑果枸杞Lycium ruthenicum是我国西北荒漠地区特有的一种具有良好保健功效的药食两用植物。现代植物化学研究发现黑果枸杞的果实中不仅含有花色苷、黄酮、生物碱、多糖等多种活性成分,还富含脂肪酸、氨基酸等多种营养物质和锰、硒、锌等微量元素。现代药理学研究表明黑果枸杞及其化学成分具有抗氧化、抗疲劳、降血糖、降血脂、保护心血管、保肝、调节免疫等多种药理活性。主要对近年来黑果枸杞的化学成分和药理活性的研究进展进行了系统综述,旨在为黑果枸杞药理活性的深入研究及相关产品的开发应用提供关键信息和参考。Lycium ruthenicum is a kind of medicinal and edible plant with excellent health-care effect, which is a unique medicinal plant in the desert region of northwest China. Phytochemical investigations have identified that the fruit of this herb contains a variety of bioactive ingredients, including anthocyanins, flavonoids, alkaloids, and polysaccharides, as well as of fatty acids, amino acids, and some trace elements(such as manganese, selenium, and zinc, etc). Modern pharmacological researches have demonstrated that both the extract of L. ruthenicum and its constituents exhibit a wide range of pharmacological activities, such as anti-oxidation, anti-fatigue, hypoglycemic and hypolipidemic activity, cardiovascular and liver protection, as well as immune-regulatory activity. The chemical constituents of L. ruthenicum and their pharmacological effects are systematically summarized in this paper, and all information presented here may strongly facilitate further investigations on the pharmacological activities of this herb and the development and applications of the related products of this herb.

关 键 词：黑果枸杞 化学成分 药理活性 花色苷 微量元素 保健功效 

分 类 号：R282.71[医药卫生—中药学]